Posted by JohnL on May 3, 2001, at 3:17:31
In reply to John L, posted by Mr.Scott on May 2, 2001, at 14:53:11
>
> Hi John,
>
> Wouldn't Zyprexa, or Amisulpiride, or Risperdal only make SSRI induced apathy worse? They Block even more Dopamine than SSRI's..no? I could understand the Ritalin, Wellbutrin, Adrafinil/Modafinil approach.. but the new antipsychotics??? It's not that I don't believe you, but rather am curious if you have postulated any theories on How this can be??
>
> Intrigue and Curiousity
>
> mr.scott
>Hi Mr Scott,
I used to be real intrigued with theory and mechanism and such. But over time it dawned on me that theories have no relation at all to whether a drug will work for someone or not. When a drug works, we really can't pinpoint exactly why. Same thing when it doesn't work. I have shifted into a pattern of thinking where I just go with what works, dump what doesn't, and leave theory to the academic world.At low doses the antipsychotics actually enhance rather than block dopamine. Presynaptic receptors are blocked which stimulates increased dopamine. At higher doses postsynaptic receptors are blocked causing a decrease of dopamine function. And like I said, theory is just theory. I cannot explain why my cocktail works. I don't really care either. Just as long as it works.
I tried a lot of drugs that looked absolutely perfect on paper. I could have told you how a drug was going to work and why it was going to work for me. The problem is, they didn't work as expected and in fact many of them made me much worse very fast. How can that be? It went against all logic. Theory predicted these drugs were for me. In fact the ones that made the most sense turned out being the worst.
John
poster:JohnL
thread:61423
URL: http://www.dr-bob.org/babble/20010424/msgs/61490.html