Posted by AndrewB on March 14, 2001, at 3:27:56
In reply to Combining D2 agonists with anti-psychotics, posted by JohnX on March 14, 2001, at 2:19:31
John,
Remember that the antipsychotics will at low doses be antagonizing the presynaptic autoreceptors while Mirapex stimualtes the post-synaptic response. So they are not, one would think conteracting one another. On person is combining rispedal with mirapex. My experience with the the combo of mirapex and amisulpride was an increase in fine motor coordination but not additional mood benefit. The 5-HT2 antagonism activitiy of antipsychotics (i.e. Zyprexa) may act synergistically with Mirapex by further enhancing certain dopamine repeptor functions. But this is just specualtion until more reports come in on such combos. I would think it prudent to trial an antipsychotic separately from the Mirapex before considering trying such a combo.AndrewB
poster:AndrewB
thread:56462
URL: http://www.dr-bob.org/babble/20010310/msgs/56466.html