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Re: treatment resistant depression » sweetmarie

Posted by SLS on March 13, 2001, at 21:21:21

In reply to Re: treatment resistant depression » SLS, posted by sweetmarie on March 13, 2001, at 19:31:14

Dear Anna,

Thank you for replying to my question.

> Trimipramine has had no side effects on me (as far as i know). It`s difficult to tell, though, as I am taking 4 different medications. I don`t feel `sedated` in any way, or at least not by Trimipramine. I am lethargic, but I think that`s to do with depression in general. In other words, my lethargy has not increased since I started taking Trimipramine. The side effects of the drug are basically the same as those of other Tricyclics (none of which spring to mind except the usual dry mouth, constipation, dizziness, possible weight gain etc.)

> Are you thinking of taking Trimipramine?

Yes.

> I don`t know how effective it is on it`s own (for `resistant` people)

I cannot affort to declare inelligible any medication at this point. I am interested in trimipramine (Surmontil) because it is the "black sheep" of the tricyclic family. It doesn't appear to do the things that were considered important for a tricyclic to do, namely the inhibition of the reuptake of norepinephrine, and to a lesser extent, serotonin. That the drug works at all speaks to how little we understand about how antidepressants work and what are the psychobiological abnormalities that cause depression and bipolar disorder.

> As I said, it`s one of four medications I am taking (Lamotragine, Valproate, Trimipramine and Phenelzine).

Have you or any member of your family been diagnosed as having bipolar disorder?

> I will be coming off the Trimipramine in order to try out this new combination.

Don't you also have to discontinue Nardil before beginning Effexor?

> Sorry to not to have been of much use.

Don't be silly. Consider yourself well used. :-)

Thanks.


- Scott

 

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