Posted by JahL on March 5, 2001, at 9:43:30
In reply to Re: The case for pindolol as an antidepressant , posted by SLS on March 5, 2001, at 8:57:49
> >
> > > > My psychiatrist has tried Pindolol over the years and had no success with anyone.
> >
> > I think the fact that most of the studies were mid-late 90's, and that clinical interest has since petered out, perhaps tells us something.
> >
> > J
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>
> Maybe. But I have read people on Psycho-Babble describe pindolol as being their savior adjunctive medication. One person tested its efficacy by removing it, only to relapse. Fortunately he was able to recover an antidepressant response upon its reintroduction.
>
> Perhaps this tells us something about clinical studies. Pindolol might be a low-percentage treatment, but I am keeping it on my list.
>
>
> - ScottYeah. Not much thought went into my last post. In fairness to Sal the available literature does suggest, quite convincingly, that Pindolol may significantly shorten the latency of onset of anti-depressive action when combined with SSRIs & possibly other ADs. Also the dosing schedule used in most studies (2.5mg t.i.d) is thought by some 2 be too low.
The evidence that Pindolol synergistically (as opposed to additively) augments ADs *beyond* the onset period is less convincing, tho' I'll keep an open mind. I, like you, put more faith in patient reports than yr average pdoc.
Jah.
poster:JahL
thread:55327
URL: http://www.dr-bob.org/babble/20010302/msgs/55610.html