Posted by Cam W. on February 23, 2001, at 11:34:56
In reply to Prozac and cold medicine???, posted by LD on February 23, 2001, at 9:14:09
LD - Dextromethorphan (DM) is primarily metabolized by a liver enzyme system (cytochrome P450-2D6 or CYP-2D6). Prozac is a potent inhibitor of this enzyme. When inhibited, there is less of this enzyme to metabolize the DM. Therefore blood levels of DM will increase and may cause hyperactivity, unsteadiness, nausea, and vomitting.
In other words, taking a normal dose of DM with Prozac is like taking a very large dose of DM at one time, therefore should be avoided.
Hope this helps - Cam
poster:Cam W.
thread:54670
URL: http://www.dr-bob.org/babble/20010221/msgs/54678.html