Posted by JohnL on December 1, 2000, at 6:05:48
In reply to Selegiline question, for AndrewB or anybody, posted by natg on November 30, 2000, at 21:35:47
> Hi All:
> I want to add 5mg of Selegiline to Risperdal.
> My only concern is can I start immediately or do I need to wait 9 days for the Prozac to be out of my system. I took it for the last time yesterday.
> I'm just concerned because I read that these drugs have severe interactions: increase risk of CNS toxicity and musle rigidity.
> But I'm wondering if this is for higher Selegiline doses ( 10mg and above)
> Anyway, any suggestions would be greatly appreciated.
> Thanks!
>
> NatI would think you would be fine breaking the tab into quarters. Start with 1/4 per day. After a week, when the Prozac is half gone, then you could go up to 1/2 per day. You might even be able to do 5mg right now. In all reality, I don't think there would be any problem combining Prozac+Selegiline unless you were taking 10mg or more per day of Selegiline. My suggestion of 1/4 per day could be excessively cautious and way too conservative. But that's just how I am when I start something new. You'll just have to feel it out and see what happens. I generally prefer to start very low at first though, and then increase once I have a feel for it. Kind of like dipping one's toes in the water before diving in.
I don't see any problem with what you want to do. I took 5mg and 10mg Selegiline about a year ago when I was also taking 20mg Prozac per day, and had no problems or adverse reactions. (except for impotence...isn't that weird...a drug that is supposed to be beneficial for sex actually made me limp? It did the same thing later even when I wasn't taking Prozac. Damn. It's not supposed to do that!) Other than that, I had no problems at all combining the two. In clinical studies they have been combined as well. Adverse events are generally not expected except with doses higher than 10mg. Regardless, I always err on the side of safety and start low.
Johnps...due to the impotence I experienced, I was not on the drug long enough to tell you if it helped or not.
poster:JohnL
thread:49725
URL: http://www.dr-bob.org/babble/20001130/msgs/49746.html