Posted by Anna P. on November 8, 2000, at 22:02:30
In reply to Re:More on Viloxazine. Betamimetic AD? Scott, posted by Anna P. on November 8, 2000, at 21:40:50
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> 1.Psychopharmacology (Berl) 1982;76(3):212-7
> Anticonvulsant and proconvulsant properties of Viloxazine hydrochloride: pharmacological and pharmacokinetic studies in rodents and the epileptic baboon.
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> 2.Neuropsychobiology 1987:17(1-2):35-40
> Viloxazine as a betamimetic antidepressant drug
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> A comparison was made between the effects of maprotiline, the sole action of which is to inhibit the reuptake of noradrenaline, of salbutamol and of viloxazine on hypothermia induced by reserpine, oxotremorine or apomorphine. The dose/effect curves in the three tests showed a similarity in profile between viloxazine and salbutamol, whereas no resemblance was evident between these two drugs and maprotiline. These facts suggest that viloxazine which has a weak effect on noradrenaline reuptake acts probably as antidepressant by betamimetic activity.
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> More...1.Minerva Med 1989 May:80(5):475-82
Nonpsychotic involutional inhibited depression and psycho-organic deteriorations:treatment with Viloxazine and piracetam.
...This report claims that combined viloxazine-piracetam is the most apropriate treatment for involutional depression. This approach
(200 mg oral viloxazine and 9 g oral piracetam a day)was adopted for 3 months in 33 outpatients about 64 years old who were subsequenly put on maintenance oses (100 mg viloxazine, 3 g piracetam a day).
The variuos Hamilton scale parameters were assessed as were reaction times to auditory and visual simple stimuli. Result sat the start and end of treatment were then compared. About three quaters of the patients showed improvement in both depression and psycho-organic syndrome symptoms, while total remission or lasting improvement in both pathologies was obtained in about 50 %.Anna P.
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