Posted by AndrewB on September 7, 2000, at 21:45:14
In reply to SAM-E appears to be working, posted by Peter S on September 7, 2000, at 20:39:51
Peter,
I hope that SAMe is the thing that you needed. Keep us posted.
I am doing really, really well; good mood, confident, good energy and motivation. I hope this is here to stay.
When compiling the amisulpride mini-survey I was reminded that you were one of the ones who didn't respond to amisulpride. Were you taking Nardil at the time? I thought that you had the perfect profile for someone that would respond; dysthymic, having social anxiety, and having responded to Nardil (whose effectiveness is in part due to dopaminergic action).
An idea keeps going through my head that some people may not respond to amisulpride yet still have D2/D3 receptor dysfunction. Maybe somehow the amisulpride doesn't work for them because it isn't able for some reason to antagonize the pre-synaptic receptors.
However, even when amisulpride fails to work, maybe another drug that works on the D2/D3 receptors may work.
I thinking of the drug Mirapex (pramipexole). It, like amisulpride, acts on the D2/D3 receptors, but it works by a very different mode of action; it is a post-synaptic agonist not a pre-synaptic antagonist like amisulpride.
The one major study done with Mirapex showed it to be quite effective for depression. When I took it I found the side effect to be mild and transient.
If you want to consider taking Mirapex, I'll be glad to send you more information on it.
AndrewB
poster:AndrewB
thread:44433
URL: http://www.dr-bob.org/babble/20000905/msgs/44455.html