Posted by stjames on August 3, 2000, at 1:14:12
In reply to Re: Ativan or Xanax? Which one is safer?, posted by kazoo on August 2, 2000, at 22:02:33
>
> Ativan is a very short acting benzo (2 to 3 hours), whereas
> Xanax is a longer acting drug; ergo, if you take Xanax at night,
> there's a good chance for a morning "hangover."James here....
I was just looking, thet have very close peaks and half lifes.
To Writ:
snipFollowing oral administration, alprazolam(Xanax) is readily absorbed. Peak concentrations in the plasma occur in 1-2 hours following administration. Plasma levels are proportionate to the dose given; over the dose range of 0.5 to 3.0 mg, peak levels of 8.0 to 37 ng/ml were observed. Using a specific assay methodology, the mean plasma elimination half-life of alprazolam has been found to be about 11.2 hours (range: 6.3-26.9 hours) in healthy adults.
snip
Lorazepam (Atavin) is readily absorbed with an absolute bioavailability of 90 percent. Peak concentrations in plasma occur approximately 2 hours following administration. The peak plasma level of lorazepam from a 2 mg dose is approximately 20 ng/ml.
The mean half-life of unconjugated lorazepam in human plasma is about 12 hours and for its major metabolite, lorazepam glucuronide,(inactive) about 18 hours. At clinically relevant concentrations, lorazepam is approximately 85% bound to plasma proteins. Lorazepam is rapidly conjugated at its 3-hydroxy group into lorazepam glucuronide which is then excreted in the urine. Lorazepam glucuronide has no demonstrable CNS activity in animals.
poster:stjames
thread:41982
URL: http://www.dr-bob.org/babble/20000729/msgs/42071.html