Posted by SLS on June 25, 2000, at 8:07:35
In reply to Re: adrafinil, posted by JohnL on June 25, 2000, at 5:55:00
Hi John.
How are you doing these days?
> > I doubt Provigil is an alpha-1 agonist as it does not prevent or mitigate cateplexy in narcolepsy.
> >
> >
> > - Scott
>
> Scott,
> You may be onto something here. I used to try amino acid supplements. At one time I focused on glutamate chemistry. I got much worse. I also got worse with Provigil. Coincidence or connection?
>
> All I know for sure is that I have tried both Provigil and Adrafinil and they are not at all similar.------------------------------------------------------
What sorts of experimentation did you conduct with glutamine/glutamate and what were the results? Is there such a thing as a glutamate supplement?I can't find any detailed information regarding the pharmacology of adrafinil. I have no idea if or how it may affect glutamate/GABA neurotransmission. I am not convinced that modafinil and adrafinil do *not* stimulate NE alpha-1 receptors directly. They may. Different study designs produce different conclusions. However, none of the ones I came across assayed the binding of either of these drugs to NE receptors. All of the evidence for noradrenergic activity was indirect and required deductive reasoning. In the abstracts and articles I have seen, adrafinil and modafinil are described as being "putative" NE alpha-1 agonists, but never refer to specific data demonstrating it. It seems more like hearsay.
Both your differing experiences with modafinil and adrafinil and the notion that NE alpha-1 agonists (naphazoline) can be used as prognosticating probes for their efficacy make understanding the mechanisms of action of these two drugs relevant to treatment. If you encounter anything, please post it.
By the way, did either adrafinil or modafinil affect your appetite or body weight?
*** So... what's your new miracle drug? I want it. Are you taking adrafinil?
Feel well.
Sincerely,
Scott
poster:SLS
thread:37844
URL: http://www.dr-bob.org/babble/20000619/msgs/38319.html