Posted by Cam W. on April 18, 2000, at 23:46:58
In reply to Re: Cam - serotonin and dopamine opposition, posted by boB on April 17, 2000, at 20:48:41
Zeke and boB - I have tried twice to post a very long answer as a follow-up to Zeke's thread. I have some very complicated info on neurotransmitter interactions, but after 1.5h of trying to post a synopsis of the studies, I will just give you the bibliography. The answers I was going to give were too involved for this site and taken out of context of the original articles may have made things more confusing.Zeke is correct about using modulating, rather than opposition when taking of the interactions between dopamine and serotonin. Stimulation of different serotonin receptor subtypes will either increase or decrease dopamine synthesis and release in different parts of the brain.
The good articles I have found on the interactions between neurotransmitters are:
Murphy D et al. Brain serotonin neurotransmission: an overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs, J Clin Psychiatry, 1998; 59[suppl 15]: 4- 12.
(yes, that is the title)Kapur S & Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia, Am J Psychiatry, April, 1996; 153(4): 466-476.
Richelson E. Receptor pharmacology of neuroleptics: relation to clinical effects, J Clin Psychiatry, 1999; 60[suppl 10] : 5-14.
Bonhomme N. Involvement of serotonin and dopamine in the mechanism of action of novel antidepressant drugs: a review, J Clin Psychopharmacol; 1998; 18(6): 447-454.
These papers should give you a descent basis for some of the neurotransmitter function. I still haven't totally grasped the concepts, yet. I think I need a few more papers and a lot more time. - Cam W.
poster:Cam W.
thread:29285
URL: http://www.dr-bob.org/babble/20000411/msgs/30524.html