Posted by Cam W. on April 16, 2000, at 21:35:14
In reply to Re: Neurotoxicity - SSRI's may not be so benign..., posted by sean on April 16, 2000, at 16:36:26
> well, I did some homework on this and TCA's and
> SRI's bind different locations of the serotonin
> neurons. both increase net serotonin transmission
> but by different means.
>
> seanSean - I find the above to be a very interesting statement.
*Could you please supply the references to back up your claims of TCAs bind to different serotonin receptors than the SSRIs?*
I was under the impression that the TCAs bound to (and affected) mainly five different receptors (serotonin reuptake, norepinephrine reuptake, muscarinic/cholinergic, alpha-adrenergic and the histamine-H1 receptors). The SSRIs, to varying degrees also bind to some of these receptors, but not usually to an appreciable extent. I thought that the TCAs and SSRIs affected the same serotonin receptors. There are at least 15 different serotonin receptor subtypes, but I have not heard of any currently marketed antidepressant to adversely affect any of these.
If you have found some new information about TCAs bind to different serotonergic receptors, I am very much interested. This may change our thinking on the long term effects of other serotonergic drugs (eg buspirone, LSD, Imitrex, etc.).
This would be ground-breaking information that I think the whole scientific community will need to embrace. Hoping to hear from you soon.
Sincerely - Cam W.
poster:Cam W.
thread:29745
URL: http://www.dr-bob.org/babble/20000411/msgs/30266.html