Posted by Cam W. on January 29, 2000, at 10:01:07
In reply to Re: Which ADs affect dopamine and norepinephrine?, posted by saint james on January 29, 2000, at 0:08:42
> > cheers!
>
> Effexor.
>
> jamesJessica & James - Actually Effexor, contrary to popular belief, is not very potent at the norepinephrine receptor, as recent receptor binding studies have borne out. See:
Tatsumi M et al, Eur J Pharmacol, 1997; 340:249-58
Cusack B et al, Psychopharmacol, 1994; 114: 559-65
Owens M et al, J Pharmacol Exp Ther, 1997; 283(3):
1305-22.The only antidepressants with both serotonin and norepinephrine reuptake blocking activities are the tricyclics (TCAs) which have varying potencies at each of these sites. Desipramine is more potent at the norepinephrine reuptake receptor, while Clomipramine is more potent at the serotonin reuptake receptor.
Many European (and North American) psychiatrists consider the TCAs to be the best antidepressants (outside of ECT - or MAOIs for psychotic or refractory depression) that we have. Their use is limited by the many annoying and potentially serious adverse effects they can produce. Many people taking TCAs for depression are non-compliant because of the side effects they can cause. With the SSRIs you give up some potency for better tolerability and safety. - Cam W.
poster:Cam W.
thread:19950
URL: http://www.dr-bob.org/babble/20000128/msgs/19980.html