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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by Dan Perkins on December 17, 2004, at 16:02:34
This is a bad combination, right?
Posted by linkadge on December 17, 2004, at 16:14:00
In reply to MAOI + Tryptophan, posted by Dan Perkins on December 17, 2004, at 16:02:34
I would say this is a bad combination. Tryptophan is strictly contraindicated when on an MAOI, I would assume the same would hold with 5-htp.
Have you tried fish oil, folic acid, or inositol ?
Linkadge
Posted by Dan Perkins on December 17, 2004, at 16:27:05
In reply to Re: MAOI + Tryptophan, posted by linkadge on December 17, 2004, at 16:14:00
I have tried fish oil. I sometimes take an 800mcg folic acid supplement, but I'm not sure what the therapeutic dose is. (do you know?)
Also, I've never tried inositol - what's the deal with it?
thx
>
> Have you tried fish oil, folic acid, or inositol ?
>
> Linkadge
Posted by linkadge on December 17, 2004, at 17:20:00
In reply to Re: MAOI + Tryptophan, posted by Dan Perkins on December 17, 2004, at 16:27:05
In males, a theraputic aumentation was seen with 1mg = 1000mcg of folic acid. So you're not too far off.
Linkadge
Posted by Larry Hoover on December 18, 2004, at 10:03:51
In reply to MAOI + Tryptophan, posted by Dan Perkins on December 17, 2004, at 16:02:34
> This is a bad combination, right?
I would say that the risk is proportional to the dose. It may be an excellent combination, but it ought to be a well thought out one.
The biggest undeterminable variable is your own biochemical response. The difference could be tenfold or more, in different people.
You get tryptophan every day, in your diet. Your brain requires some tryptophan every day. There already is an interaction between the MAOI and tryptophan, but the magnitude of the interactions cannot be known accurately. If you want to tweak tryptophan, you need to be able to do it with precise control. I'd say dose control at the 100 mg level would be necessary.
And, it would be a good idea that you recognize the symptoms of serotonin syndrome. Here's one resource: http://www.anxiety-and-depression-solutions.com/serotonin-syndrome.htmLar
Posted by Dan Perkins on December 18, 2004, at 20:40:27
In reply to Re: MAOI + Tryptophan » Dan Perkins, posted by Larry Hoover on December 18, 2004, at 10:03:51
So, the idea seems to be that MAOI + Tryptophan is a no no for the same reasons that MAOI + SSRIs is a no no. In my mind, this is a good indication that Tryptophan really is powerful enough to effect serotonin levels and that it may just be a good thing for me.
> I would say that the risk is proportional to the dose. It may be an excellent combination, but it ought to be a well thought out one.
>
> The biggest undeterminable variable is your own biochemical response. The difference could be tenfold or more, in different people.
>
> You get tryptophan every day, in your diet. Your brain requires some tryptophan every day. There already is an interaction between the MAOI and tryptophan, but the magnitude of the interactions cannot be known accurately. If you want to tweak tryptophan, you need to be able to do it with precise control. I'd say dose control at the 100 mg level would be necessary.
> And, it would be a good idea that you recognize the symptoms of serotonin syndrome. Here's one resource: http://www.anxiety-and-depression-solutions.com/serotonin-syndrome.htm
>
> Lar
>
This is the end of the thread.
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