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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by undopaminergic on December 31, 2022, at 13:55:06
I'm on vortioxetine 5 mg/day and have been on it for about 3 weeks.
I had the opportunity to perform a little experiment.
Caffeine alone normally does nothing for me, even at high doses. Once, I took 3000 mg and got no stimulant effect. All it did was give me the worst night in my whole life, as I got extremely sick to my stomach.
Caffeine does work very well for me with a proper dopaminergic stimulant like methyl- or ethylphenidate in the background. It adds a major nootropic dimension to the dopaminergic drug. I get an almost "flight" of ideas, a cavalcade of interesting ideas. Furthermore, it has general, "normal" stimulant effects like enhancement of wakefulness.
So, I was going to see how caffeine worked with vortioxetine in the background. So, I took 500 mg, and I was pleasantly surprised! I wasn't expecting any effect at all, but I felt less apathetic, more awake, more attentive, and more energetic. I read some neuroscientific (full) articles and was comprehending them well.
Alas, I was unable to reproduce the experience the day after with the same 500 mg amount. It may be that a higher dose would have worked, but I didn't want to get into a chase for a high that takes higher and higher doses.
Has anyone else found that caffeine only works in combination with other drugs? Which ones?
-undopaminergic
Posted by beckett2 on January 1, 2023, at 18:43:27
In reply to Vortioxetine plus caffeine, posted by undopaminergic on December 31, 2022, at 13:55:06
Trintellix (20 mg) doesn't potentiate my caffeine in any way. I could drink a cup of coffee before bed.
Posted by beckett2 on January 1, 2023, at 18:45:25
In reply to Vortioxetine plus caffeine, posted by undopaminergic on December 31, 2022, at 13:55:06
3,000 mg! I bet you had a bad night :(
Do you watch Chubby Emu's YouTube channel? Not that you approached the levels of this guy
Posted by undopaminergic on January 3, 2023, at 9:49:31
In reply to Re: Vortioxetine plus caffeine » undopaminergic, posted by beckett2 on January 1, 2023, at 18:45:25
> 3,000 mg! I bet you had a bad night :(
>Yeah. I was desperate to get up and out of the apathy. Caffeine was the only stimulant I had.
> Do you watch Chubby Emu's YouTube channel?
No.
> Not that you approached the levels of this guy
>
> https://youtu.be/sylqJ0NEVJw
>Interesting!
-undopaminergic
This is the end of the thread.
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