Psycho-Babble Medication Thread 1121433

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One Drug - Opposite Effects - Different brain?

Posted by SLS on December 31, 2022, at 16:55:36

I have never seen the following taken into consideration. None of my doctors ever did. However, it is really just common sense.

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* A single drug can have opposite effects depending on the drug that preceded it.

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Something very curious happened to me after I failed to respond to vortioxetine. I switched immediately to Effexor without a waiting period. For all practical purposes, I had been used in an experiment in which vortioxetine was used as a pre-treatment to a challenge by Effexor. Of course, the dynamics of brain function were altered by vortioxetine before Effexor was introduced. Although the pharmacodynamics of Effexor were exactly the same, it wasn't being introduced to the same brain. It acted like a completely different drug than the one I was familiar with. It significantly increased the severity of depression and left me in a brain-fog that came close to feeling like derealization. It took about 2 weeks for my head to clear after I discontinued Effexor.


- Scott

 

Re: One Drug - Opposite Effects - Different brain? » SLS

Posted by beckett2 on January 1, 2023, at 19:03:34

In reply to One Drug - Opposite Effects - Different brain?, posted by SLS on December 31, 2022, at 16:55:36

>pre-treatment to a challenge

I've never heard of this. I recall your negative experience with trintellix. Intuitively, this idea makes sense, but intuition itself isn't proof.

 

Re: One Drug - Opposite Effects - Different brain? » beckett2

Posted by SLS on January 2, 2023, at 11:57:16

In reply to Re: One Drug - Opposite Effects - Different brain? » SLS, posted by beckett2 on January 1, 2023, at 19:03:34

> >pre-treatment to a challenge
>
> I've never heard of this. I recall your negative experience with trintellix. Intuitively, this idea makes sense, but intuition itself isn't proof.

That is a perspective that should be considered by every novice. True scientists are frustratingly objective and logical sometimes.

The only fact that I need to work with is that I felt horrendous after switching from vortioxetine to venlafaxine, whereas venlafaxine had always provided a partial improvement for decades previously.

n=1 Anecdotal.

Personally, I think that a good doctor will consider the anecdotes that come through his office as an aid in making treatment decisions.


- Scott


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