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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by Jay2112 on May 25, 2022, at 2:11:12
I have been experimenting lately...mostly with larger doses of anti-inflammatory drugs (NSAIDS) for some of my brutal headaches and body aches. Done a couple times a day, it feels like a major 'lift', enabling me to great extents. And it brings, surprisingly, a relief to my mind.
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https://www.nature.com/articles/d41586-018-05261-3The Inflamed Mind: A Radical New Approach to Depression Edward Bullmore Short (2018)
Depression affects one in four people at some time in their lives. It is often difficult to treat, in part because its causes are still debated. Psychiatrist Edward Bullmore is an ardent proponent of a radical theory now gaining traction: that inflammation in the brain may underlie some instances. His succinct, broad-brush study, The Inflamed Mind, looks at the mounting evidence.
Posted by SLS on May 25, 2022, at 6:37:23
In reply to Radical new theory..Inflamation causes depression., posted by Jay2112 on May 25, 2022, at 2:11:12
> I have been experimenting lately...mostly with larger doses of anti-inflammatory drugs (NSAIDS) for some of my brutal headaches and body aches. Done a couple times a day, it feels like a major 'lift', enabling me to great extents. And it brings, surprisingly, a relief to my mind.
> -----------------------------------------
> https://www.nature.com/articles/d41586-018-05261-3
>
> The Inflamed Mind: A Radical New Approach to Depression Edward Bullmore Short (2018)
>
> Depression affects one in four people at some time in their lives. It is often difficult to treat, in part because its causes are still debated. Psychiatrist Edward Bullmore is an ardent proponent of a radical theory now gaining traction: that inflammation in the brain may underlie some instances. His succinct, broad-brush study, The Inflamed Mind, looks at the mounting evidence.
Not so new. Not so radical. But...Monocycline is a particularly good anti-inflammatory that reduces the release of pro-inflammatory cytokines from microglia cells in the brain. I found it helpful enough to take it for over a year. However, one of the possible side effects of monocycline is hyperpigmentation of the feet and shins. It looks like dirt or black-and-blue marks, and is sometimes irreversible. It usually doesn't show up for a year or more of taking it continuously.
There have been a few experiments using celecoxib (Celebrex), a NSAID that is specific for COX-2, in depression. The few things I read about this treatment indicated that it wasn't robust enough to look into it further.
https://pubmed.ncbi.nlm.nih.gov/?term=minocycline+depression&sort=relevance
- Scott
Posted by Hugh on May 27, 2022, at 11:56:18
In reply to Radical new theory..Inflamation causes depression., posted by Jay2112 on May 25, 2022, at 2:11:12
A low dose of radiation -- the amount used in a CT scan -- has a powerful anti-inflammatory effect. Low-dose radiotherapy is being studied as a treatment for Covid-19 Pneumonia, osteoarthritis, Alzheimer's and depression.
https://www.frontiersin.org/articles/10.3389/fimmu.2021.777792/full
Posted by Christ_empowered on May 27, 2022, at 20:48:54
In reply to Re: Radical new theory..Inflamation causes depression., posted by Hugh on May 27, 2022, at 11:56:18
I've found astaxanthin has improved my mood, over time. Antioxidant, higher doses seem to have anti-inflammatory effects. considered curcumin, but it seems that absorption and drug interactions are more of an issue.
I take the 12mgs capsules.
Posted by Hugh on June 8, 2022, at 18:50:57
In reply to Radical new theory..Inflamation causes depression., posted by Jay2112 on May 25, 2022, at 2:11:12
Specialized pro-resolving mediators (SPMs) have been getting a lot of attention lately because of their anti-inflammatory properties.
https://www.lifeextension.com/magazine/2019/ss/resolve-and-repair-inflammatory-damage
https://www.frontiersin.org/articles/10.3389/fncel.2021.673549/full
SPMs can be purchased here:
https://www.lifeextension.com/vitamins-supplements/item02223/pro-resolving-mediators
Posted by Lamdage22 on June 11, 2022, at 1:41:29
In reply to Re: Radical new theory..Inflamation causes depression., posted by Hugh on June 8, 2022, at 18:50:57
Thanks for sharing. This is the main reason why I follow this board.
> Specialized pro-resolving mediators (SPMs) have been getting a lot of attention lately because of their anti-inflammatory properties.
>
> https://www.lifeextension.com/magazine/2019/ss/resolve-and-repair-inflammatory-damage
>
> https://www.frontiersin.org/articles/10.3389/fncel.2021.673549/full
>
> SPMs can be purchased here:
>
> https://www.lifeextension.com/vitamins-supplements/item02223/pro-resolving-mediators
Posted by Lamdage22 on June 11, 2022, at 11:55:57
In reply to Re: Radical new theory..Inflamation causes depression., posted by Lamdage22 on June 11, 2022, at 1:41:29
I ordered that stuff. It takes 30 days to come here because I am not in the US. It sounds promising.
Posted by Hugh on June 15, 2022, at 19:43:03
In reply to Re: Radical new theory..Inflamation causes depression., posted by Lamdage22 on June 11, 2022, at 11:55:57
You're welcome. I hope pro-resolving mediators help you. Another supplement that might interest you is ergothioneine.
https://www.lifeextension.com/magazine/2022/3/mushroom-support-healthy-aging
Ergothioneine capsules are shipped from the EU at
https://www.lifeextensioneurope.com/essential-youth-l-ergothioneine
Posted by Lamdage22 on June 29, 2022, at 14:15:09
In reply to Re: Radical new theory..Inflamation causes depression. » Lamdage22, posted by Hugh on June 15, 2022, at 19:43:03
It was a scam. It is not available in my german speaking country
This is the end of the thread.
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