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Dr. Bob is Robert Hsiung, MD,
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Posted by jay2112 on July 8, 2021, at 11:42:58
"The norepinephrine reuptake transporter is responsible for removing dopamine from the synapse in this area of the brain. Blockade of these transporters by agents such nortriptyline can acutely increase dopamine levels in the frontal cortex, facilitating dopaminergic function."
Posted by linkadge on July 8, 2021, at 18:22:41
In reply to Nortriptyline Increases Dopamine...., posted by jay2112 on July 8, 2021, at 11:42:58
Yes, and norepinephrine reuptake inhibitors also increase dopamine in the hippocampus. Some of the other actions of nortriptyline (5-ht2 antagonism, and muscarinic antagonism) will also increase dopamine.
Linkadge
Posted by jay2112 on July 9, 2021, at 18:58:20
In reply to Re: Nortriptyline Increases Dopamine...., posted by linkadge on July 8, 2021, at 18:22:41
> Yes, and norepinephrine reuptake inhibitors also increase dopamine in the hippocampus. Some of the other actions of nortriptyline (5-ht2 antagonism, and muscarinic antagonism) will also increase dopamine.
>
> LinkadgeI find it fascinating, all of the use of 5-htp antagonism, and inverse agonists, treating multiple disorders. I have a very good response to 5-ht2a and 5-ht2c subreceptor antagonists. Those same chemicals are used for disorders right across the psychiatric spectrum...MDD, bipolar, schizophrenia, AD(H)D, etc. Leading me to believe that the pharma industry SHOULD be making drugs that are true selective serotonin combination agonists/antagonists/inverse agonists. And take away the dopamine antagonists. (For use in non-psychotic Dx's)
Anyhow...I am rambling on. Lol. Your thoughts?
Jay
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