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Dr. Bob is Robert Hsiung, MD,
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Posted by Hugh on July 5, 2021, at 10:59:14
The psychedelic drug psilocybin, a naturally occurring compound found in some mushrooms, has been studied as a potential treatment for depression for years. But exactly how it works in the brain and how long beneficial results might last is still unclear.
In a new study, Yale researchers show that a single dose of psilocybin given to mice prompted an immediate and long-lasting increase in connections between neurons. The findings are published July 5 in the journal Neuron.
"We not only saw a 10% increase in the number of neuronal connections, but also they were on average about 10% larger, so the connections were stronger as well," said Yale's Alex Kwan, associate professor of psychiatry and of neuroscience and senior author of the paper.
Previous laboratory experiments had shown promise that psilocybin, as well as the anesthetic ketamine, can decrease depression. The new Yale research found that these compounds increase the density of dendritic spines, small protrusions found on nerve cells which aid in the transmission of information between neurons. Chronic stress and depression are known to reduce the number of these neuronal connections.
They found increases in the number of dendritic spines and in their size within 24 hours of administration of psilocybin. These changes were still present a month later. Also, mice subjected to stress showed behavioral improvements and increased neurotransmitter activity after being given psilocybin.
"It was a real surprise to see such enduring changes from just one dose of psilocybin," he said. "These new connections may be the structural changes the brain uses to store new experiences."
Complete article:
https://medicalxpress.com/news/2021-07-psychedelic-spurs-growth-neural-lost.html
Posted by linkadge on July 5, 2021, at 17:14:57
In reply to Psychedelic spurs growth of neural connections, posted by Hugh on July 5, 2021, at 10:59:14
Very cool.
Linkadge
Posted by linkadge on July 11, 2021, at 11:54:01
In reply to Re: Psychedelic spurs growth of neural connections, posted by linkadge on July 5, 2021, at 17:14:57
I wonder if they know the receptor / mechanism that is involved.
Linkadge
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