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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by undopaminergic on May 25, 2021, at 6:34:44
Researching asenapine, I came across this:
https://pubmed.ncbi.nlm.nih.gov/25522408/
Title: "Adjunctive treatment with asenapine augments the escitalopram-induced effects on monoaminergic outflow and glutamatergic neurotransmission in the medial prefrontal cortex of the rat".Quote: "The present study shows that addition of low doses (0.05 and 0.1 mg/kg) of asenapine to escitalopram (5 mg/kg) markedly enhances dopamine, noradrenaline, and serotonin release in the rat mPFC as well as dopamine release in the nucleus accumbens.".
-undopaminergic
Posted by Christ_empowered on May 25, 2021, at 10:48:27
In reply to SSRIs with atypical antipsychotics, posted by undopaminergic on May 25, 2021, at 6:34:44
thanks for the link.
i have only a -very- rudimentary understanding of all this. the animal data you provided a link to sounds similar to the data for symbyax, the zyprexa-prozac combo pill for treatment-resistant depression and bipolar I depression.
i'm...not a big fan of tranquilizers, honestly. at least, not as permanent, never ending, ongoing treatment. in addition to some evidence that seems to indicate serious potential for drug-induced problems in large groups of treated people (social withdrawal, apathy, risk of cardiac events, choking, weight and metabolic problems), I have found, personally...
the tranquilizers were helpful, possibly necessary, for a period of my life. now? now, I'm honestly beginning to wonder if I've somehow reached a point at which some problems which I -strongly- suspect are either drug-induced or at least exacerbated by the drugs...
might actually outweigh any benefits, now and for the foreseeable future. but the label/diagnosis is permanent, it seems. oh well.
Posted by linkadge on May 25, 2021, at 17:37:11
In reply to SSRIs with atypical antipsychotics, posted by undopaminergic on May 25, 2021, at 6:34:44
Yeah, it's probably an effect of interaction with 5-ht1a / 5-ht2ac receptors. Similar effects are noted with other atypicals (like olanzapine) or mirtazapine.
Of note though, the drug itself may block some of its own effect. For example, it may release dopamine, but then also block dopamine receptors (i.e. in the NAC) blocking some of the effect of this monoamine increase.
Last week, my sleep got really messed up again. I ended up taking a small dose of olanzapine and amitriptyline. I was surprised that my mood improved quite a bit over the next few days. I have a love hate relatinship with effexor. It really makes me flat.
Linkadge
Posted by rjlockhart37 on May 27, 2021, at 0:48:40
In reply to SSRIs with atypical antipsychotics, posted by undopaminergic on May 25, 2021, at 6:34:44
i take prozac and zyprexa, for years. It's acutally a med called Symbax, mixture of it. But they say this combination is used for treatment resistant depression. Zyprexa first used is sedating at doses above 10mg. But, it seems to have an antidepressant effect ironicly
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