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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on December 17, 2019, at 17:27:31
I have been reading some articles on original comparisons between imipramine and phenelzine. Many (if not most) studies indicated the phenelzine was more effective than imipramine.
Interesting.
Linkadge
Posted by undopaminergic on December 18, 2019, at 6:58:05
In reply to Original MAOI vs TCA studies, posted by linkadge on December 17, 2019, at 17:27:31
> I have been reading some articles on original comparisons between imipramine and phenelzine. Many (if not most) studies indicated the phenelzine was more effective than imipramine.
>
> Interesting.
>
> LinkadgeRight. However, here's an exception:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1597363/pdf/brmedj00101-0007.pdfI discovered this article while I was researching trimipramine, which I'm currently taking.
-undopaminergic
Posted by sigismund on December 18, 2019, at 15:08:07
In reply to Re: Original MAOI vs TCA studies » linkadge, posted by undopaminergic on December 18, 2019, at 6:58:05
I really liked low dose trimpiramine.
Posted by linkadge on December 18, 2019, at 16:22:44
In reply to Re: Original MAOI vs TCA studies » linkadge, posted by undopaminergic on December 18, 2019, at 6:58:05
Interesting. Of note, they said mild-moderate (not sure if severity is an issue). Also, supposedly there are some differences in response between melancholic and atypical subtypes.
I've been adding some MAOI herbs to venlafaxine and often notice a dramatic improvement.
Linkadge
Posted by linkadge on December 18, 2019, at 16:24:38
In reply to Re: Original MAOI vs TCA studies, posted by sigismund on December 18, 2019, at 15:08:07
I would second that. I found trimipramine better than mirtazapine. On paper, they should be similar. Trimipramine had more of an anti-anhedonic effect. Not sure why.
Linkadge
Posted by undopaminergic on December 19, 2019, at 7:18:55
In reply to Re: Original MAOI vs TCA studies » sigismund, posted by linkadge on December 18, 2019, at 16:24:38
> I would second that. I found trimipramine better than mirtazapine. On paper, they should be similar. Trimipramine had more of an anti-anhedonic effect. Not sure why.
>
> LinkadgeI wouldn't go so far as to call it anti-anhedonic, but I've noticed some anti-apathetic effects myself, especially at the start, with a dose of only 25 mg. I found it gave me more of a choice over whether to be active or rest.
I notice less with 50 mg, which I've been on for months now.
I think these effects may be related to the fact that it is a histamine H2-receptor antagonist. See the studies of famotidine in schizophrenia.
-undopaminergic
Posted by linkadge on December 20, 2019, at 19:54:20
In reply to Re: Original MAOI vs TCA studies » linkadge, posted by undopaminergic on December 19, 2019, at 7:18:55
All I remember from trimipramine was sleeping till 3pm and then waking up and feeling great - like I had entered a new world. Things looked and felt different - a newness.
Linkadge
This is the end of the thread.
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