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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 10 of 10. This is the beginning of the thread.
Posted by PeterMartin on June 19, 2019, at 11:08:07
Just a heads up that "Sonosi" (Jazz pharma's solriamfetol) just received it's class scheduling (IV) and will be available in early July. I bet it'll be extremely expensive but hopefully there'll be samples to try. I'd love to hear from anyone who gives it a go. It's only currently approved for narcolepsy but it's being tried for other conditions.
"Sunosi, a first-in-class dual-acting dopamine and norepinephrine reuptake inhibitor (DNRI), was approved in March 2019 to improve wakefulness in adult patients with excessive daytime sleepiness "
"Sunosi is expected to be available in 75mg (functionally scored) and 150mg tablets in early July. "
Posted by SLS on June 19, 2019, at 14:23:07
In reply to Solriamfetol (new DNRI for wakefulness) avail July, posted by PeterMartin on June 19, 2019, at 11:08:07
Thanks!
- Scott
> Just a heads up that "Sonosi" (Jazz pharma's solriamfetol) just received it's class scheduling (IV) and will be available in early July. I bet it'll be extremely expensive but hopefully there'll be samples to try. I'd love to hear from anyone who gives it a go. It's only currently approved for narcolepsy but it's being tried for other conditions.
>
> https://www.empr.com/home/news/wakefulness-promoter-sunosi-designated-schedule-iv-controlled-substance/
>
> "Sunosi, a first-in-class dual-acting dopamine and norepinephrine reuptake inhibitor (DNRI), was approved in March 2019 to improve wakefulness in adult patients with excessive daytime sleepiness "
>
> "Sunosi is expected to be available in 75mg (functionally scored) and 150mg tablets in early July. "
Posted by rjlockhart37 on June 19, 2019, at 17:50:36
In reply to Solriamfetol (new DNRI for wakefulness) avail July, posted by PeterMartin on June 19, 2019, at 11:08:07
that sounds intresting because it's the first since wellbutrin, there used to be DNRI's back in the 60s, like preludin, i think. The only other DRNI is Prolintane, it was used in the 50s and down. But it's not very potent. It just gives you bump up. Not a psychostimulant
this is gonna be intresting when it hits the pharma market
Posted by sigismund on June 20, 2019, at 15:19:42
In reply to Re: Solriamfetol (new DNRI for wakefulness) avail July, posted by rjlockhart37 on June 19, 2019, at 17:50:36
There is a big difference between Preludin and prolintane.
Posted by SLS on June 20, 2019, at 17:38:50
In reply to Solriamfetol (new DNRI for wakefulness) avail July, posted by PeterMartin on June 19, 2019, at 11:08:07
The best example of a DNRI antidepressant I know of is nomifensine (Merital). It was available briefly in the 1980s, and helped a great many people. Nomifensine was withdrawn worldwide by the manufacturer (Hoechst-Roussel) when a few cases of hemolytic anemia were reported in Europe. I responded to it briefly in a way similar to the way I respond to tricyclics. Some very desperate people were forced to give up the only antidepressant that ever worked for them.
- Scott
Posted by Christ_empowered on June 20, 2019, at 20:12:17
In reply to Re: Solriamfetol (new DNRI for wakefulness) avail July, posted by SLS on June 20, 2019, at 17:38:50
was amineptine a dnri?
Posted by rjlockhart37 on June 21, 2019, at 1:16:05
In reply to Re: Solriamfetol (new DNRI for wakefulness) avail July, posted by sigismund on June 20, 2019, at 15:19:42
yes i know, phenmetrazine is a dopamine release also norephineprhine ... it's strong and potant, prolintane is mild DRNI, i've tried prolintane before but i don't want talk much but it's very mild, nothing like main stimulants
Posted by SLS on June 21, 2019, at 7:41:21
In reply to Re: Solriamfetol (new DNRI for wakefulness) avail July, posted by Christ_empowered on June 20, 2019, at 20:12:17
> was amineptine a dnri?
Amineptine was generally described as being selective for dopamine.
- Scott
Posted by Christ_empowered on June 21, 2019, at 10:41:43
In reply to Re: Solriamfetol (new DNRI for wakefulness) avail July, posted by rjlockhart37 on June 19, 2019, at 17:50:36
phendimetrazine (Bontril, etc.) is still available. I don't know how popular it is. I find it strange...adderall, etc. are seen as "medicines," but diet pills are still stigmatized. Anyway...
its Schedule III, so refills are technically a possibility. Some of it...30%, I think...is metabolized to phenmetrazine, but since its a pro-drug and I think its usually prescribed in the SR capsule form, the abuse potential is much lower than Preludin.
and now you know. :-)
Posted by pedr on June 22, 2019, at 12:59:44
In reply to Solriamfetol (new DNRI for wakefulness) avail July, posted by PeterMartin on June 19, 2019, at 11:08:07
Am I right in thinking that the only other "wakefulness promoting agent" out there is Pro/Nuvigil?
I respond briefly and intermittently to those, which is actually a big deal for me since I'm so treatment resistant. Having another arrow in that quiver (or whatever the saying is) would be great. I really hope it gets approved for MDD or anxiety.
This is the end of the thread.
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