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Dr. Bob is Robert Hsiung, MD,
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Posted by PeterMartin on April 19, 2019, at 12:27:56
Anti-Inflammatory Add-On May Be Beneficial for Depression https://www.empr.com/home/news/anti-inflammatory-add-on-may-be-beneficial-for-depression/
See below. Iirc SLS tried an Anti-inflammatory for depression but eventually developed a skin reaction. Is anyone else using an anti-inflammatory as part of their regime? BTW I've seen studies that say OTC anti-inflammatory meds are NOT good for depression and can make it worse (Re: Ibuprofen/Etc daily)
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April 19, 2019HealthDay News Anti-inflammatory add-on treatment is beneficial for patients with major depressive disorder (MDD) or depressive symptoms, according to a meta-analysis published in the May issue of Acta Psychiatrica Scandinavica.
Ole Köhler-Forsberg, from Aarhus University Hospital in Denmark, and colleagues performed a systematic review of randomized clinical trials (RCTs) studying antidepressant treatment effects and side effects of pharmacological anti-inflammatory interventions in adults with MDD or depressive symptoms. Data were included for 36 RCTs, of which 13 investigated nonsteroidal anti-inflammatory drugs (4214 patients), nine cytokine inhibitors (3345 patients), seven statins (1576 patients), three minocyclines (151 patients), two pioglitazones (77 patients), and two glucocorticoids (59 patients).
The researchers found that compared with placebo, anti-inflammatory agents improved depressive symptoms as an add-on in patients with MDD (standardized mean difference [SMD], −0.64) and as monotherapy (SMD, −0.41). Response and remission were improved with an anti-inflammatory add-on (risk ratios, 1.76 and 2.14, respectively). A trend toward increased risk for infections was seen; a high risk for bias was observed in all studies.
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Whats persuasive is that weve found that several of the anti-inflammatory drugs have what can be characterized as a medium to a large effect on depression and depressive symptoms, in particular because the results build on almost 10,000 people who have participated in the placebo-controlled studies with anti-inflammatory treatment, a coauthor said in a statement. The results from the meta-analysis are particularly promising not only because of an effect of the anti-inflammatory medicine on its own but also due to the supplementary effect when the anti-inflammatory medicine is given simultaneously with the antidepressants that are used today.
Posted by linkadge on April 19, 2019, at 15:11:02
In reply to Anti-Inflammatory Add-On for Depression (Study), posted by PeterMartin on April 19, 2019, at 12:27:56
Yes, I have read studies that suggest both and enhancement and inhibition of antidepressant response.
A few thoughts I have are:
1) It may depend on the anti-inflammatory used. Some of them have additional targets. For example, I believe diclofenac inhibits sodium channels.
2) It may depend on the type of illness. Some depression (perhaps anxious) may be associated with increased inflammation and other types may be associated with immune suppression.
3) It may depend on the genetics of the patient
4) It may depend on the phase of the illness. When an animal, for instance, is subjected to stress, the immune system is activated. Over time, however, the immune system becomes exhausted and there is immune suppression.
Personally, I find anti-inflammatories beneficial, but I use them as needed.
Linkadge
This is the end of the thread.
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