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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by joe f on April 11, 2019, at 15:12:43
it seems as if this medication rarely gets mentioned.....any experiences with it as an add on to an ssri......or is really just a tweaked abilify
Posted by Christ_empowered on April 12, 2019, at 7:12:14
In reply to rexulti experiences, posted by joe f on April 11, 2019, at 15:12:43
hi. you might want to skim psych forums...i seem to recall some posters there on rexulti and/or vraylar, mostly for more severe problems.
keep in mind; its very new. and...i think some doctors have reluctance to prescribe it as heavily as, say, latuda because its another D2 partial agonist. not only is Abilify now generic (and there's a long acting injection available, too), but D2 partial agonists in psychiatry are a relatively new -thing-.
i first took abilify in 03 or 04...i forget. it was a last ditch effort to find a tranquilizer that I could tolerate, because zyprexa and seroquel had been failures. it worked! but i remember the shrink basically saying no one knew much about it and the only available data was from the manufacturer. i felt like a guinea pig, which seems to be standard in psychiatric 'treatment.'
anyway...hope things get better in your world. have you tried abilify?
Posted by joe f on April 12, 2019, at 8:34:54
In reply to Re: rexulti experiences, posted by Christ_empowered on April 12, 2019, at 7:12:14
what is the function of a d-2 partial agonist that rexilti hits
Posted by Christ_empowered on April 12, 2019, at 10:24:33
In reply to Re: rexulti experiences, posted by joe f on April 12, 2019, at 8:34:54
like abilify, the idea is that instead of blocking D2 receptors, like most antipsychotics/neuroleptics, it "occupies" the receptor, blocking normal dopamine transmission and also offering some ability to stimulate the same receptor. I'm not a science person, but...
this seems to translate--with Abilify, at least--into less EPS, less dysphoria, less...typical neuroleptic experiences, basically. And yet...it still gets the job done, for most people, in Bipolar I, mania, Schizophrenia, Schizoaffective, etc.
with abilify, some animal studies have shown that there's less pronounced brain changes from long term treatment than with, say, zyprexa or haldol. i think animal studies hint at a lower risk of tardive dyskinesia, too, but...
-all- neuroleptics can cause: neuroleptic malignancy syndrome, EPS, dysphoria, TD, akathisia, possibly tardive dementia (I think that's usually associated with tardive dyskinesia and/or tardive akathisia, but not always...).
there's the controversial concept of "tardive psychosis," which means that administering a neuroleptic can cause people who had never previously experienced psychosis to experience psychosis, probably because of changes to brain structure. along the same lines, there's an emerging awareness that while drugs suppress key symptoms, there seem to be cases where the problems get worse, not better. and so...
one has "treatment resistant depression" emerging from antidepressant usage; severe anxiety from benzodiazepine use; and tardive psychosis from neuroleptics. but...
even with all that, there are people/patients who clearly do far better -on- psych drugs than off psych drugs. personally, i think the big, big problem is that so many people have been exposed to so many drugs for problems that might not have been treated with drugs (or with anything, at all) 20, 30 years ago. :-(
Posted by joe f on April 12, 2019, at 10:56:51
In reply to Re: rexulti experiences, posted by Christ_empowered on April 12, 2019, at 10:24:33
thanx very interesting.......i am on 2 mg of rexuli now to add on to luvox......no one knows if theres an interaction ...i was told no.....
Posted by pedr on April 14, 2019, at 19:48:59
In reply to rexulti experiences, posted by joe f on April 11, 2019, at 15:12:43
> it seems as if this medication rarely gets mentioned.....any experiences with it as an add on to an ssri......or is really just a tweaked abilify
Hi, I've been on 2mg for a couple of months along with Fetzima. Because I was on multiple meds is hard to say exactly what we down to the Rexulti. However it seemed to do very little indeed for my TR depression and OCD.
I'm on Lexapro and abilify now and whilst still very depressed, am doing much better. YMMV as always of course.
Pete
Posted by joe f on April 16, 2019, at 10:05:42
In reply to Re: rexulti experiences » joe f, posted by pedr on April 14, 2019, at 19:48:59
so you feel rexulti is weaker less effective than abilify?
Posted by pedr on April 16, 2019, at 13:46:34
In reply to Re: rexulti experiences » joe f, posted by pedr on April 14, 2019, at 19:48:59
> > it seems as if this medication rarely gets mentioned.....any experiences with it as an add on to an ssri......or is really just a tweaked abilify
>
> Hi, I've been on 2mg for a couple of months along with Fetzima. Because I was on multiple meds is hard to say exactly what we down to the Rexulti. However it seemed to do very little indeed for my TR depression and OCD.
>
> I'm on Lexapro and abilify now and whilst still very depressed, am doing much better. YMMV as always of course.
>
> PeteHi Joe, well like I said, it's hard to separate out the effects of the meds. Plus I'm very atypical and frequently have paradoxical reactions to meds. As always, YMMV and you might have to see how it goes for yourself.
Pete
Posted by joe f on April 16, 2019, at 15:21:33
In reply to Re: rexulti experiences » pedr, posted by pedr on April 16, 2019, at 13:46:34
thanks what the heck....did you put on much weight with rexulti/abilify?
Posted by pedr on April 16, 2019, at 17:30:01
In reply to Re: rexulti experiences, posted by joe f on April 16, 2019, at 15:21:33
> thanks what the heck....did you put on much weight with rexulti/abilify?
I did the first time I was on Abilify but not subsequently. Maybe it's because I've been on lower doses since, I don't know.
Posted by joe f on April 16, 2019, at 18:17:18
In reply to Re: rexulti experiences » joe f, posted by pedr on April 16, 2019, at 17:30:01
what do you think 2 mg of rexulti would be oa abilify approximately
This is the end of the thread.
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