![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 22 of 22. This is the beginning of the thread.
Posted by Hugh on December 22, 2018, at 15:21:19
One of the drugs discussed in this article is SAGE-17, which might have to be taken only once a month, or even less frequently.
Posted by Lamdage22 on December 22, 2018, at 16:47:42
In reply to Promising depression drugs to watch for in 2019, posted by Hugh on December 22, 2018, at 15:21:19
WHen could it be expected to hit the market?
Posted by Hugh on December 22, 2018, at 17:22:04
In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on December 22, 2018, at 16:47:42
A phase 3 clinical trial for postpartum depression is expected to be released in January. If the trial is a success, SAGE-217 could receive FDA approval for PPD by late 2019. Sage is recruiting now for their phase 3 trial for major depressive disorder. If this trial is a success, SAGE-217 could receive FDA approval for MDD in 2020 or 2021. However, if SAGE-217 is approved for PPD in 2019, physicians would be able to prescribe it off-label for MDD, bipolar I/II disorder, and insomnia.
Posted by Phillipa on December 22, 2018, at 17:23:22
In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on December 22, 2018, at 16:47:42
If this sage targets Gaba does the mean it might be good for anxiety? Phillipa
Posted by Hugh on December 22, 2018, at 22:57:42
In reply to Re: Promising depression drugs to watch for in 2019, posted by Phillipa on December 22, 2018, at 17:23:22
> If this sage targets Gaba does the mean it might be good for anxiety? Phillipa
In the clinical trials, it has performed significantly better than placebo for anxiety.
Posted by Hugh on December 22, 2018, at 23:00:21
In reply to Promising depression drugs to watch for in 2019, posted by Hugh on December 22, 2018, at 15:21:19
I should have written SAGE-217.
> One of the drugs discussed in this article is SAGE-17, which might have to be taken only once a month, or even less frequently.
>
> https://amp.businessinsider.com/most-promising-new-depression-drugs-treatments-predictions-2019-2018-12
Posted by Lamdage22 on December 23, 2018, at 3:43:52
In reply to Re: Promising depression drugs to watch for in 2019, posted by Hugh on December 22, 2018, at 23:00:21
Thanks for posting. I wasnt aware of this at all.
Posted by linkadge on December 23, 2018, at 6:53:29
In reply to Promising depression drugs to watch for in 2019, posted by Hugh on December 22, 2018, at 15:21:19
Sage-217 is an interesting one. Many of the SSRIs indirectly target the same neurosteroid pathway. As a positive gaba-a modulator, it could also replace the use of benzodiazapines for some people.
I have been benefitting from CBD which is also a positive modulator of the gaba-a receptor.Linkadge
Posted by Lamdage22 on December 23, 2018, at 9:09:29
In reply to Re: Promising depression drugs to watch for in 2019, posted by linkadge on December 23, 2018, at 6:53:29
i wonder if there are sexual or metabolic side effects
Posted by Phillipa on December 23, 2018, at 9:30:18
In reply to Re: Promising depression drugs to watch for in 2019, posted by linkadge on December 23, 2018, at 6:53:29
48 years of benzos now low dose one time a day any hope of even getting off the benzos. Wow can't believe how old I am now. And I often wonder if taking them is responsible for loss of taste and smell 15 years now. And I really don't feel the benzos work any longer. It seems if something is bothering me I just don't sleep even with them. Phillipa
Posted by Lamdage22 on December 23, 2018, at 11:18:58
In reply to Re: Promising depression drugs to watch for in 2019 » linkadge, posted by Phillipa on December 23, 2018, at 9:30:18
Its not unusual to not feel benzos anymore after a while. I am amazed that they worked for so long. If i take like 2-3 Ativans, i dont feel it anymore. I must not take it for peanuts in order for it to work in an emergency.
Posted by Phillipa on December 23, 2018, at 11:52:29
In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on December 23, 2018, at 11:18:58
This is why I am pretty sure they don't anymore. Wonder what would happen if just stopped them since two one at a time? Sometimes I cut the dose and nothing happens? Phillipa
Posted by Lamdage22 on December 23, 2018, at 12:26:46
In reply to Re: Promising depression drugs to watch for in 2019 » Lamdage22, posted by Phillipa on December 23, 2018, at 11:52:29
I would be careful and taper gradually. Sometimes withdrawal symptoms are delayed. You may get sick if you just stop. Id do 10% steps with dissolved benzo.
Posted by Phillipa on December 23, 2018, at 17:30:33
In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on December 23, 2018, at 12:26:46
I take 7.5mg of valium a night and then .75mg of xanax? Is this high? Phillipa
Posted by Lamdage22 on December 24, 2018, at 4:23:56
In reply to Re: Promising depression drugs to watch for in 2019 » linkadge, posted by Phillipa on December 23, 2018, at 9:30:18
Its not much but your brain is likely used to that alot. You wont do yourself a favor to just quit abruptly. I think if your will is strong to get off you can do it. I always recommend the website https://www.survivingantidepressants.org
They have lots of experience with withdrawing. Be warned though, they dont like meds.
Posted by Phillipa on December 24, 2018, at 8:58:05
In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on December 24, 2018, at 4:23:56
Thanks I know you are correct. Phillipa
Posted by SLS on December 24, 2018, at 10:31:11
In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on December 23, 2018, at 12:26:46
> I would be careful and taper gradually. Sometimes withdrawal symptoms are delayed.
This is true of Abilify. Some people don't get withdrawal effects until 3 weeks after their last dose. Anxiety is a big one.
- Scott
Posted by Lamdage22 on January 1, 2019, at 5:14:42
In reply to Re: Promising depression drugs to watch for in 2019 » Lamdage22, posted by SLS on December 24, 2018, at 10:31:11
This Sage-217 is a mystery to me. What is the mode of action? Does it work for anxiety? Is it ok when you are inclined towards psychosis? What are side effects and risks?
Posted by Lamdage22 on January 1, 2019, at 5:49:48
In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on January 1, 2019, at 5:14:42
Can i drive?
Posted by Hugh on January 11, 2019, at 11:10:13
In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on January 1, 2019, at 5:49:48
> Can i drive?
That shouldn't be a problem.
Posted by Hugh on January 11, 2019, at 11:15:56
In reply to Re: Promising depression drugs to watch for in 2019, posted by Lamdage22 on January 1, 2019, at 5:14:42
> This Sage-217 is a mystery to me. What is the mode of action? Does it work for anxiety? Is it ok when you are inclined towards psychosis? What are side effects and risks?
"Its mechanism of action is unknown, but it appears to be a positive allosteric modulator of GABA-A receptors with a binding site distinct from benzodiazepines."
The above quote is from the FDA Briefing Document for brexanolone, the intravenous form of SAGE-217.
Posted by Lamdage22 on January 11, 2019, at 11:42:29
In reply to Re: Promising depression drugs to watch for in 2019 » Lamdage22, posted by Hugh on January 11, 2019, at 11:15:56
Cool and the risks? Unknown?
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.