![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 16 to 40 of 50. Go back in thread:
Posted by SLS on September 1, 2018, at 7:54:23
In reply to Re: Latuda for depression - Anyone?, posted by Lamdage22 on September 1, 2018, at 7:30:09
> Could the anxiety be a result of discontinuing Neuroleptics?
I don't think so. I had discontinued Abilify before discontinuing Parnate. The brain fog / depression / anxiety didn't emerge until I was on Trinellix for two weeks. What a mess. I'm happy that I discontinued the Parnate. It left me feeling lazy and unmotivated, even though it helped the depression somewhat. I had taken it for over three years. It really was a dead end. Of course, I wish that I had tried Effexor instead of Trintellix, but going with Trintellix was the logical move. My doctor had seen several people with chronic TRD respond to it. It was something that I had not yet tried, and it was significantly different from other serotonergic drugs. Effexor has produced mild improvements in the past, but I wasn't taking the other drugs I'm currently on. I actually read a book while taking Effexor years ago. I have read only two books in my adult life. The other book I read was during a short remission produced by taking Parnate + desipramine.
- Scott
Posted by Lamdage22 on September 3, 2018, at 13:41:19
In reply to Re: Latuda for depression - Anyone? » Lamdage22, posted by SLS on September 1, 2018, at 7:54:23
Im not the most avid reader , either. :) Unfortunately.
Posted by Lamdage22 on September 3, 2018, at 22:35:52
In reply to Re: Latuda for depression - Anyone? » Lamdage22, posted by SLS on September 1, 2018, at 7:54:23
Arent withdrawal symptoms of Neuroleptics delayed sometimes?
Posted by SLS on September 4, 2018, at 7:37:07
In reply to Re: Latuda for depression - Anyone?, posted by Lamdage22 on September 3, 2018, at 22:35:52
> Arent withdrawal symptoms of Neuroleptics delayed sometimes?
I have never heard that before. Maybe.
Abilify has a 72 hour half-life.
- Scott
Posted by Lamdage22 on September 4, 2018, at 9:16:55
In reply to Re: Latuda for depression - Anyone?, posted by SLS on September 4, 2018, at 7:37:07
Well when i reduced the Neuroleptics i noticed the effects 2-3 weeks later. I was being anxious. According to several withdrawal forums this is quite common. Just a thought.
Posted by SLS on September 4, 2018, at 10:24:40
In reply to Re: Latuda for depression - Anyone?, posted by Lamdage22 on September 4, 2018, at 9:16:55
> Well when i reduced the Neuroleptics i noticed the effects 2-3 weeks later. I was being anxious. According to several withdrawal forums this is quite common. Just a thought.
I think you are right, Lamdage.
I now recall that a friend of mine experienced a delayed withdrawal reaction to Abilify discontinuation. I think it took two weeks to emerge.
- Scott
Posted by Lamdage22 on September 4, 2018, at 12:02:11
In reply to Re: Latuda for depression - Anyone?, posted by SLS on September 4, 2018, at 10:24:40
So if that were true, would it change your choices?
Posted by Lamdage22 on September 6, 2018, at 3:14:31
In reply to Re: Latuda for depression - Anyone?, posted by Lamdage22 on September 4, 2018, at 12:02:11
I would go back on a lower dose of AP if i were you. You took it for a long time and your brain got used to it. If Effexor works out you may titrate down, if you have to get on Nardil titrate up.
You should mention possible AP withdrawal effects to your doc. Most docs have little experience with withdrawing medications. All they do is put people ON medication.
I cant imagine that you would have prolonged negative effects after taking sth. for 10 days. What do you think? Does the anxiety get better?
Posted by SLS on September 6, 2018, at 8:40:57
In reply to Re: Latuda for depression - Anyone?, posted by Lamdage22 on September 4, 2018, at 12:02:11
> So if that were true, would it change your choices?
I began taking Effexor three days ago at 37.5 mg/day. I don't expect to feel better right away.
I pray this combination treatment helps.
Effexor
Nortiptyline
Lamictal
Lithium
Prazosin
- Scott
Posted by Lamdage22 on September 6, 2018, at 12:22:11
In reply to Re: Latuda for depression - Anyone? » Lamdage22, posted by SLS on September 6, 2018, at 8:40:57
Me too, Scott. It did help me. But obviously not like bringing remission. Just a partial response.
I have gone through my second day at vocational rehab from 09:30 through 14:30... it has not stopped me from going to the gym after. I think i am on a good path.
Posted by ed_uk2010 on September 7, 2018, at 13:52:18
In reply to Re: Latuda for depression - Anyone? » Lamdage22, posted by SLS on September 6, 2018, at 8:40:57
> > So if that were true, would it change your choices?
>
> I began taking Effexor three days ago at 37.5 mg/day. I don't expect to feel better right away.Any side effects this time or has it been ok?
Posted by Lamdage22 on September 14, 2018, at 2:10:16
In reply to Re: Latuda for depression - Anyone? » SLS, posted by ed_uk2010 on September 7, 2018, at 13:52:18
Hey Scott,
how is it going?
Posted by SLS on September 14, 2018, at 8:11:07
In reply to Re: Latuda for depression - Anyone?, posted by Lamdage22 on September 14, 2018, at 2:10:16
> Hey Scott,
>
> how is it going?Hi, Lamdage.
I am still struggling. I restarted Effexor 11 days ago at a dosage of 37.5 mg/day. I am now taking 150 mg/day. On day 3, I experienced a potent antidepressant effect - something I haven't felt in years. It lasted for several hours before fading. Since then, my depression has been pretty bad, and there is still some residual brain-fog from taking Trintellix. There are times when I remain motionless, staring into space. I am demoralized and have lost some of my will to fight. I am not suicidal right now, but I do worry about becoming so. My outlook has not been good. Fortunately, I have two good friends and some family. I am grateful that you and other babblers check up on me from time to time.
I am worn out. Things could be worse, though.
- Scott
Posted by Lamdage22 on September 14, 2018, at 12:02:20
In reply to Re: Latuda for depression - Anyone? » Lamdage22, posted by SLS on September 14, 2018, at 8:11:07
And your results with Nardil were not lasting? Why do you think that Nardil rather than Parnate may help you?
Posted by Lamdage22 on September 14, 2018, at 12:08:02
In reply to Re: Latuda for depression - Anyone?, posted by Lamdage22 on September 14, 2018, at 12:02:20
Hang in there! For all we know there might be a new antidepressant that helps you and then you can have a mellow life.
Posted by Lamdage22 on September 14, 2018, at 12:18:02
In reply to Re: Latuda for depression - Anyone?, posted by Lamdage22 on September 14, 2018, at 12:08:02
Im not doing too well myself. I had a family meeting over the werkend that has set me back. I puked and then i left. Very uptight people. I havent been to vocational rehab all week. I called in sick. Doing nothing wreaks havoc on my mental health. Looking forward to monday.
Posted by Lamdage22 on September 19, 2018, at 6:42:28
In reply to Re: Latuda for depression - Anyone?, posted by Lamdage22 on September 14, 2018, at 12:18:02
Scott,
did you ever go to an endocrinologist? DHEA, Testosterone and HGH would come to my mind. Inbalances can cause depression.
Posted by Lamdage22 on September 19, 2018, at 6:48:26
In reply to Endocrinologist?, posted by Lamdage22 on September 19, 2018, at 6:42:28
i think at your age its likely. Of course HRT has side effects, too but they may be less than meds.
Posted by SLS on September 19, 2018, at 8:14:48
In reply to Re: Endocrinologist?, posted by Lamdage22 on September 19, 2018, at 6:48:26
> i think at your age its likely. Of course HRT has side effects, too but they may be less than meds.
Thanks for the good suggestions. I have tried thyroid hormones, but not testosterone.
I still react badly to Effexor, even at a dosage of 37.5 mg/day. I have decided to discontinue it. I feel better today for having done so. Something has changed. I don't seem to be able to take serotonin reuptake inhibitors anymore. Scary. I am going to ask my doctor to go on Nardil. Parnate does not help me with anhedonia or my ability to perform tasks that take more than a few minutes. I have been on Nardil before. It has helped me in the past, but I don't remember exactly why I didn't continue with it. Side effects with Nardil are worse than those of Parnate for me. I experience urinary retention, profuse sweating, anorgasmia, and dizziness.
I hate going back on a MAOI.
Currently:
Nortriptyline 100 mg/day
Lamictal 300 mg/day
Lithium 300 mg/day
Prazosin 30 mg/day
- Scott
Posted by Lamdage22 on September 19, 2018, at 9:17:28
In reply to Re: Endocrinologist? » Lamdage22, posted by SLS on September 19, 2018, at 8:14:48
Sorry Scott,
and human growth hormone can be good. Maybe you can ask for a blood test of T and HGH.
Depression has gotten worse with age right?
Posted by Lamdage22 on September 19, 2018, at 10:45:12
In reply to Re: Endocrinologist?, posted by Lamdage22 on September 19, 2018, at 9:17:28
I am on a bodybuilding website and they say physiologic doses of T can completely turn your life around when you were deficient. I have talked to a few people there.
Posted by SLS on September 19, 2018, at 23:48:43
In reply to Re: Endocrinologist?, posted by Lamdage22 on September 19, 2018, at 9:17:28
> Sorry Scott,
>
> and human growth hormone can be good. Maybe you can ask for a blood test of T and HGH.
>
> Depression has gotten worse with age right?Definitely.
- Scott
Posted by Lamdage22 on September 20, 2018, at 8:20:52
In reply to Re: Endocrinologist? » Lamdage22, posted by SLS on September 19, 2018, at 23:48:43
Thats a clue.. You still have things untried! Many. To me Blueberries made a difference. Go figure.
Posted by sigismund on September 20, 2018, at 19:45:15
In reply to Re: Endocrinologist? » Lamdage22, posted by SLS on September 19, 2018, at 8:14:48
Was it that you didn't really feel stable (or something like that) on it and felt that ultimately it was not as good for your mental health than Parnate?
Posted by SLS on September 20, 2018, at 22:59:23
In reply to Re: Endocrinologist? » SLS, posted by sigismund on September 20, 2018, at 19:45:15
Hi Sigi.
> Was it that you didn't really feel stable (or something like that) on it and felt that ultimately it was not as good for your mental health than Parnate?
I usually remember these things. I honestly don't know why I asked to be switched from Nardil to Parnate. I doubt it was because of side effects, though. Parnate is a dead-end for me. I like that it helps with mental energy and concentration, but it doesn't really produce a global antidepressant effect. In the past, Nardil has come closer to doing this. Perhaps there were diminishing returns over time. I am still experiencing residual adverse mental effects from taking Trintellix, even though I discontinued the drug over a month ago. They are subsiding gradually. They appear in waves and can last for hours.
- Scott
Go forward in thread:
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.