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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 4 of 4. This is the beginning of the thread.
Posted by JohnBoy2000 on August 3, 2018, at 18:52:43
Basically - I tried combining it with high dose atomoxetine - low dose effexor - no tolerance for it.
Could it work with - high dose effexor - low dose atomoxetine?
So - I normally dose Strattera/Atomoxetine in the morning.I wanted to add in a serotonergic component - so I tried Effexor.
It combined awfully dosed simultaneously with Atomoxetine in the morning - so I tried it at 4 pm - and it was better tolerated.
I can't dose it at night - as it induces insomnia like that.
I dosed it to a max of 75 mg - as that was all I could tolerate.But ultimately - I had to taper off it as, although I benefited, the long term interaction proved to be negative.
So - Atomoxetine, I dose it high at 80 mg - activating - fantastic restoration of functionality.I am considering reducing this dose, instead dosing Effexor in the morning to 225 mg - the activating dose - and using Atomoxetine as a "booster" of the noradrenergic effect, as it were.
I have no idea how that will work out.
Is it possible it may be tolerated given the dose increase/decrease, in contrast to the initially poorly tolerated approach?
As to the underlying pharmacology - technically Effexor has a favourable interaction profile but - it didn't work out that way before.
Can anyone lend some kind of insight as to this?
Posted by rjlockhart37 on August 3, 2018, at 22:50:16
In reply to Combining Effexor n Atomoxetine; can it be done?, posted by JohnBoy2000 on August 3, 2018, at 18:52:43
effexor works more on norepinephrine at higher doses, and dopamine, i don't really have an answer, it could work and could make too much NE that would be unpleasant
Posted by Christ_empowered on August 4, 2018, at 19:35:24
In reply to Combining Effexor n Atomoxetine; can it be done?, posted by JohnBoy2000 on August 3, 2018, at 18:52:43
are stimuants and option? I would think effexor+ritalin, focalin...perphaps even an amphetamine...would be more effective, maybe safer, too.
Posted by linkadge on August 6, 2018, at 14:03:02
In reply to Re: Combining Effexor n Atomoxetine; can it be done?, posted by Christ_empowered on August 4, 2018, at 19:35:24
There is no direct interaction between Effexor and atomoxetine. Effexor has a much weaker effect on norepinephrine than it does serotonin. Adding atomoxetine would produce a greater inhibition of the norepinephrine transporter.
That being said, you're likely to get additional norepinephrine related side effects (i.e. possibly higher blood pressure and/or pulse).
Linkadge
This is the end of the thread.
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