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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by linkadge on March 30, 2018, at 18:18:54
https://www.ncbi.nlm.nih.gov/pubmed/22133541
The sustained activation of monoaminergic neurons by cannabinoid drugs can also be related to changes in the function of presynaptic inhibitory α(2)-adrenoceptors or 5-HT(1A) receptors (autoreceptors and heteroreceptors), whose sensitivity is downregulated or upregulated upon chronic CB(1) agonist exposure.
Posted by SLS on March 30, 2018, at 23:31:13
In reply to CB1 agonism 5-ht1a autoreceptor desensitization, posted by linkadge on March 30, 2018, at 18:18:54
> https://www.ncbi.nlm.nih.gov/pubmed/22133541
>
> The sustained activation of monoaminergic neurons by cannabinoid drugs can also be related to changes in the function of presynaptic inhibitory α(2)-adrenoceptors or 5-HT(1A) receptors (autoreceptors and heteroreceptors), whose sensitivity is downregulated or upregulated upon chronic CB(1) agonist exposure.How does this translate clinically?
- Scott
Posted by linkadge on March 31, 2018, at 9:59:16
In reply to Re: CB1 agonism 5-ht1a autoreceptor desensitization, posted by SLS on March 30, 2018, at 23:31:13
Who knows, but it is suggesting that it desensitizes 5-ht and NE autoreceptors. In theory, this is a proposed target of antidepressants.
Linkadge
Posted by bleauberry on April 9, 2018, at 13:25:32
In reply to CB1 agonism 5-ht1a autoreceptor desensitization, posted by linkadge on March 30, 2018, at 18:18:54
I don't know what this means clinically. In my experience I have not seen armchair quarterbacking pay off good dividends very often.
But I can tell you for sure there is high potential in marijuana for psychiatric patients. I know 2 people personally who were psychiatric basket cases, including psychiatric wards and institutionalization. They have nearly normal lives today - work, hobbies, everything - and their only medication is marijuana.
They failed meds, inpatient treatment, and everything. But their lives were almost fully restored rapidly - and still enduring now, years later - with marijuana.
It deserves note that their doses are high - they both smoke frequently during the day and they consume edibles also - their tolerance so high that they don't get high anymore, their eyes do not get red or glassy. They just get normal.
So while the armchair quarterbacking on cannabis and psychiatry is interesting to talk about, I have seen it work miracles that I did not see happen in psychiatry.
15% of the population has a gene that makes them susceptible to depression/anxiety/schizo from marijuana. But everyone else could find benefit.
imo
> https://www.ncbi.nlm.nih.gov/pubmed/22133541
>
> The sustained activation of monoaminergic neurons by cannabinoid drugs can also be related to changes in the function of presynaptic inhibitory α(2)-adrenoceptors or 5-HT(1A) receptors (autoreceptors and heteroreceptors), whose sensitivity is downregulated or upregulated upon chronic CB(1) agonist exposure.
Posted by Lamdage22 on April 10, 2018, at 9:23:24
In reply to Re: CB1 agonism 5-ht1a autoreceptor desensitization, posted by bleauberry on April 9, 2018, at 13:25:32
What gene is that? I think i have it:)
Posted by Prefect on April 15, 2018, at 1:04:36
In reply to Re: CB1 agonism 5-ht1a autoreceptor desensitization, posted by Lamdage22 on April 10, 2018, at 9:23:24
What about THC free nonpsychoative CBD oil? Has anyone tried it?
Posted by Lamdage22 on April 16, 2018, at 6:14:33
In reply to Re: CB1 agonism 5-ht1a autoreceptor desensitization, posted by Lamdage22 on April 10, 2018, at 9:23:24
Yes i did but it made me extremely anxious. Most people have a different experience though.
This is the end of the thread.
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