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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by PeterMartin on January 29, 2018, at 3:00:18
I know his sounds counterintuitive but I've been taking modafinil/armodafinil for over a year now. Im dxed bp1 and I wouldn't say I have the typical response to provigil/Nuvigil. They're very mild and I can sleep on them w.o. issue. They also seem to slow me down. It's not necessarily good in that sense....like I don't feel anywhere near as creative or productive but sometimes I wonder if it helps to keep my brain from going too far down the path to mania.....
Im pretty sure I saw a study or two checking to see it the adinils were ok for bipolar where there were less "switches" to mania in the afinil groups.
Am I completely wrong that this could be possible? Anyone familiar with it's brain activity who could make a case either for or against that theory?
Just a discussion.
Posted by PeterMartin on January 29, 2018, at 3:02:58
In reply to Could Provigil / Nuvigil be antimanic?, posted by PeterMartin on January 29, 2018, at 3:00:18
Btw: On the other hand typical stimulants like Ritalin and Adderall have been in my system a few times when I've gone manic. I feel they're risky and if anything push me towards mania.
Posted by SLS on January 29, 2018, at 9:18:47
In reply to Re: Could Provigil / Nuvigil be antimanic?, posted by PeterMartin on January 29, 2018, at 3:02:58
> Btw: On the other hand typical stimulants like Ritalin and Adderall have been in my system a few times when I've gone manic. I feel they're risky and if anything push me towards mania.
You might find this helpful:
Use of adjunctive stimulants in adult bipolar depression
https://academic.oup.com/ijnp/article/16/1/55/629710
- Scott
Posted by PeterMartin on January 29, 2018, at 13:12:46
In reply to Re: Could Provigil / Nuvigil be antimanic?, posted by SLS on January 29, 2018, at 9:18:47
> > Btw: On the other hand typical stimulants like Ritalin and Adderall have been in my system a few times when I've gone manic. I feel they're risky and if anything push me towards mania.
>
> You might find this helpful:
>
> Use of adjunctive stimulants in adult bipolar depression
>
> https://academic.oup.com/ijnp/article/16/1/55/629710
>
>
> - ScottThank you!
--
Armodafinil 150 mg/d (n = 128) and placebo (n = 129) were administered once daily in the morning. The primary outcome measure was change from baseline in the total 30-item IDS score. Secondary outcomes included changes from baseline in scores on the MontgomeryÅsberg Depression Rating Scale (MADRS; Montgomery & Åsberg, 1979), as well as IDS and MADRS response rates. At endpoint, adjunctive armodafinil compared to adjunctive placebo yielded significantly greater improvement in mean IDS scores, but failed to separate on any of the secondary outcomes. Most frequently reported adverse events in patients receiving adjunctive armodafinil were headache, diarrhoea, and insomnia. Of note, armodafinil was not associated with an increased incidence and/or severity of suicidality, depression, or mania or with changes in metabolic profile measurements.
===
I wish it made me feel a little better (or less slow) but at least there's some proof it shouldn't cause mania on its own.I wish I could switch to something like Vyvanse or Concerta as I think these would do more to help me be productive (and stay awake). That said I think there is potential for someone to go manic on those (especially when combined w/ an MAOI and limited anti-manic stabilizers).
Currently:
Nardil 60 (recent chance from Marplan)g
Armodafinil 150 to 200 (Morning/Evening)
Lamictal 150
Metformin 1000 (starting)
Seroquel 25mg (Sleep but will prob increase to 50/100)
Posted by Christ_empowered on January 30, 2018, at 6:57:51
In reply to Re: Could Provigil / Nuvigil be antimanic?, posted by PeterMartin on January 29, 2018, at 13:12:46
hi. Ritalin was, once, fairly popular for various forms of depression. i guess because its somewhat milder than an amphetamine? it was also somewhat popular in treating some people with Schizophrenia, to counteract sedation from the tranquilizer and elevate mood.
if you don't like how the provigil affects you, id personally think about asking the doctor for a switch to something else. i think there's more research on ritalin and the amphetamines for depression than provigil or nuvigil. i would assume most of the stimulants are also less expensive than provigil, also.
This is the end of the thread.
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