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Dr. Bob is Robert Hsiung, MD,
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Posted by phidippus on October 7, 2017, at 18:36:18
Is Trintellix a relatively weak SRI?
Eric
Posted by linkadge on October 8, 2017, at 7:50:32
In reply to Trintellix...Weaker SRI?, posted by phidippus on October 7, 2017, at 18:36:18
Looking in Wikipedia:
https://en.wikipedia.org/wiki/Vortioxetine
it has a ki for the serotonin transporter similar to SSRIs. However, it also has relatively strong effects on other serotonin receptors i.e. 5-ht1a.
So, perhaps the alternative mechanisms allow one to take the drug at a dose where serotonin reuptake inhibition is less prominent than with SSRIs.
I would have to look for a study which investigates the degree of serotonin transporter binding, at therapeutic doses of the drug.
Linkadge
Posted by SLS on October 8, 2017, at 13:49:21
In reply to Re: Trintellix...Weaker SRI?, posted by linkadge on October 8, 2017, at 7:50:32
Trintellix:
5-HT7 antagonism is being looked at as being a mechanism to promote antidepressant effects.
- Scott
Posted by phidippus on October 8, 2017, at 14:36:36
In reply to Re: Trintellix...Weaker SRI?, posted by SLS on October 8, 2017, at 13:49:21
Posted by linkadge on October 8, 2017, at 15:15:54
In reply to Re: Trintellix...Weaker SRI?, posted by phidippus on October 8, 2017, at 14:36:36
Yeah, it's actually got a couple of mechanisms which make it interesting.
It is a 5-ht1a agonist and 5-ht1b agonist.
Both of these have antidepressant effects. 5-ht1b agonists probably have even more antidepressant and anti-OCD effects than 5-ht1a agonists (5-ht1a agonists being more effective for anxiety).It is a 5-ht1d antagonist, which might offset some of the negative hormonal effects of the SSRI effect (i.e. grown hormone blunting).
It is a 5-ht3 antagonist, which might contribute to anti-anxiety effects, and offset SSRI nausea.
And, as SLS mentions, it is a 5-ht7 antagonist - which can have faster acting antidepressant effects (especially in changing depression associated sleep changes).
This is the end of the thread.
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