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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by JohnBoy2000 on November 16, 2016, at 9:12:03
Several clinical trials on pubmed claim it has good efficacy.
Then the FDA halted approval as their trials demonstrated lack of efficacy.
Then there was talk of how their trials were conducted poorly and that was issue, and the the drug itself.So, apparently it's growing in popularity.
Does anyone have experience with it?
And know if it actually works or not?
Posted by rjlockhart37 on November 16, 2016, at 20:35:35
In reply to Does Reboxetine actually work?, posted by JohnBoy2000 on November 16, 2016, at 9:12:03
robexetine is a norepinephrine reptake inhibitor, so it only targets norepinephrine, not serotonin....i've read many times it's better as a add on med, i read a few sources on google that by itself is not as effective as the other AD's.....but NE makes you alert, awake, attentive, somwhwat stimulating, yet still serotonin has a big play in depression, like prozac i take the maximum dose, and i do notice that serotonin is increased because i notice during the day i feel in content, positive mood, and i notice if i go 2 days without it, i sink and get very gloomy....it gives kinda a positive feeling
robexetine would be best for low energy, sluggish depression similar to wellbutrin, yet only targeting NE.....but it's best as an add on to an SSRI
Posted by chumbawumba on January 6, 2017, at 4:15:04
In reply to Does Reboxetine actually work?, posted by JohnBoy2000 on November 16, 2016, at 9:12:03
> Several clinical trials on pubmed claim it has good efficacy.
>
> Then the FDA halted approval as their trials demonstrated lack of efficacy.
> Then there was talk of how their trials were conducted poorly and that was issue, and the the drug itself.
>
> So, apparently it's growing in popularity.
>
> Does anyone have experience with it?
> And know if it actually works or not?I tried it , it did jack for me. The only thing I can say for it is that it didn't have any sexual side effects. It actually didn't have any effects really except making me feel like I drank too much bad office coffee.
Posted by JohnBoy2000 on January 6, 2017, at 4:57:30
In reply to Re: Does Reboxetine actually work?, posted by chumbawumba on January 6, 2017, at 4:15:04
>
> I tried it , it did jack for me. The only thing I can say for it is that it didn't have any sexual side effects. It actually didn't have any effects really except making me feel like I drank too much bad office coffee.
What other meds have you tried before/zince?I'm just curious as to whether any other noadrenergic based drugs were useful for you?
Posted by chumbawumba on January 6, 2017, at 6:07:15
In reply to Re: Does Reboxetine actually work?, posted by JohnBoy2000 on January 6, 2017, at 4:57:30
> >
> > I tried it , it did jack for me. The only thing I can say for it is that it didn't have any sexual side effects. It actually didn't have any effects really except making me feel like I drank too much bad office coffee.
>
>
> What other meds have you tried before/zince?
>
> I'm just curious as to whether any other noadrenergic based drugs were useful for you?
>I've tried just aboout all of them but in terms ones with NARI activity, desipramine and Effexor. And the MAOIs Moclobemide and Parnate. Although the latter two don't increase NA by a reuptake blockade obviously. Honestly I made a list of medications I've tried once and it was over twenty and probably another dozen trials of augmentation agents. So I'm probably forgetting some or I'm not aware of the neurotransmitter profiles of some I've taken.
What works for me is ketamine+lithium. It's the best by far, so far. But it's taken some experimentation to get it right because I 'm doing intranasal ketamine. I've found that the intramuscular injections were too much too fast. So the trick is to try to duplicate what happens when you get an infusion. You take a spray wait five minutes, take a another spray, wait five minutes. Basically so you are just dancing around the edge of the psychotomimetic effects, you feel trippy but not stoned off your *ss like an IM shot will do. And you just drag that out for an hour or so. And then I'm good for a couple days.
Posted by JohnBoy2000 on January 6, 2017, at 6:11:58
In reply to Re: Does Reboxetine actually work?, posted by chumbawumba on January 6, 2017, at 6:07:15
Hmm - so, did you find them other noradrenergic agents just as useless as reboxetine - for your condition?
Obviously I'm trying to get a sense as to whether it was ineffective, specifically to you - or just in general.
Just out of curiousity - where did you obtain a nasal ketamine spray?I am considering trying dextromethorphan, but it's a relavtiely weak NMDA antagonist, acts mostly on serotonin, and serontonergics are counderproductive for me really.
Well - they certainly don't benefit.
Posted by JohnBoy2000 on January 6, 2017, at 13:18:06
In reply to Re: Does Reboxetine actually work?, posted by chumbawumba on January 6, 2017, at 6:07:15
> >
>
> I've tried just aboout all of them but in terms ones with NARI activity, desipramine and Effexor. And the MAOIs Moclobemide and Parnate. Although the latter two don't increase NA by a reuptake blockade obviously. Honestly I made a list of medications I've tried once and it was over twenty and probably another dozen trials of augmentation agents. So I'm probably forgetting some or I'm not aware of the neurotransmitter profiles of some I've taken.
>
> What works for me is ketamine+lithium. It's the best by far, so far. But it's taken some experimentation to get it right because I 'm doing intranasal ketamine. I've found that the intramuscular injections were too much too fast. So the trick is to try to duplicate what happens when you get an infusion. You take a spray wait five minutes, take a another spray, wait five minutes. Basically so you are just dancing around the edge of the psychotomimetic effects, you feel trippy but not stoned off your *ss like an IM shot will do. And you just drag that out for an hour or so. And then I'm good for a couple days.Hmm - so, did you find them other noradrenergic agents just as useless as reboxetine - for your condition?
Obviously I'm trying to get a sense as to whether it was ineffective, specifically to you - or just in general.
Just out of curiousity - where did you obtain a nasal ketamine spray?I am considering trying dextromethorphan, but it's a relavtiely weak NMDA antagonist, acts mostly on serotonin, and serontonergics are counderproductive for me really.
Well - they certainly don't benefit.
Posted by chumbawumba on January 6, 2017, at 23:13:26
In reply to Re: Does Reboxetine actually work?, posted by JohnBoy2000 on January 6, 2017, at 6:11:58
> Hmm - so, did you find them other noradrenergic agents just as useless as reboxetine - for your condition?
>
> Obviously I'm trying to get a sense as to whether it was ineffective, specifically to you - or just in general.
>
>
> Just out of curiousity - where did you obtain a nasal ketamine spray?
>
> I am considering trying dextromethorphan, but it's a relavtiely weak NMDA antagonist, acts mostly on serotonin, and serontonergics are counderproductive for me really.
> Well - they certainly don't benefit.I wasn't aware there was still interest in Reboxetine. It's still not approved in the US. I had to import it from somewhere. The wiki entry says that Pfizer withheld data and a meta analysis of all the published AND unpublished studies showed it to be ineffective and potentially harmful. It's good for ADHD apparently though.
Anyway.
The only medication I've taken comparable to Reboxetine in it's specificity is desipramine and even that if I recall was as an augmentation for Prozac. But neither reboxetine by itself or desipramine plus Prozac in the long term helped much. Although I got by with plain old Prozac for several years.If it is stimulation you are looking for I recommend Provigil. For a while there they didn't know how it worked but I was looking at the wiki for it today and I guess they have discovered it is a dopamine reuptake inhibitor. It's stimulating but not like Ritalin or Amphetamine, more mild, but good for attention and energy in general.
Regarding ketamine, here in the US ketamine is being used more and more it seems. There are ketamine infusion clinics popping up like mushrooms. And most of the infusion clinics put their patients on ketamine spray for maintenance after their IV infusion(s). The spray itself has to be obtained from a compounding pharmacy. Meaning a pharmacy that doesn't just sell pills, they will make you a ketamine ointment if that is what your doctor wants. They make liquid preparations for people who can't take pills. And since ketamine is usually only administered from a little sterile glass vial and shot into an IV drip I assume they have a way of ordering the bulk powder and dissolving and preserving it and dispensing it in a little nasal spray bottle. Just like a nasal spray of decongestant for allergies. Except a few sprays of this in each nostril and you'll be tripping balls.
As far as using DXM, I occasionally go over to bluelight.org and I just searched their forums for "DXM" and "depression" in the post title and got nine hits. Most of them small discussions but one had 45 replies so you might sign up for an account over their and see what other's experience has been. Lot of people there are trying to self medicate depression with Special K off the streets or methoxetamine which is a designer drug like ketamine but longer lasting.
I don't know how DXM works but there has been some research published just this year on ketamine and, at least in mice, it seems that it is an active metabolite that is doing the work and it's not at the NMDAR. It's all a little over my head frankly but I try to understand what I can:
Posted by chumbawumba on January 7, 2017, at 6:25:15
In reply to Re: Does Reboxetine actually work?, posted by JohnBoy2000 on January 6, 2017, at 13:18:06
Was thinking of you and found this. Recreational drug enthusiasts sometimes seem to know more than Doctors about using drugs. Especially using drugs "off-label" like DXM.
This is the end of the thread.
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