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Dr. Bob is Robert Hsiung, MD,
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Posted by joef on October 11, 2016, at 22:22:25
which ssri is the oldest?
Posted by rjlockhart37 on October 11, 2016, at 23:22:54
In reply to oldest ssri, posted by joef on October 11, 2016, at 22:22:25
Prozac - released in 1987, it's the least selective SSRI through.....meaning it effects more broad serotonin receptors and some dopamine, others like Luvox or Lexerpro are very selective and only work on certain serotonin receptors
r
Posted by SLS on October 12, 2016, at 6:39:44
In reply to oldest ssri, posted by joef on October 11, 2016, at 22:22:25
> which ssri is the oldest?
That's a difficult question to answer without specifying what criteria to use. For instance, zimelidine (Zelmid) was the first SSRI to be approved for sale, and was debuted in Europe. However, it was soon discovered that it caused a sometimes fatal GuillainBarré syndrome. Indalpine was next, but turned out to precipitate agranulocytosis, and was subsequently removed. The first SSRI to remain on the market was fluvoxamine (Luvox). It was originally called clovoxamine.
In the United States of America, the first SSRI to be marketed was fluoxetine (Prozac). I think sertraline (Zoloft) was the second. Meanwhile, citalopram (Celexa) was developed in Europe as paroxetine (Paxil) was being approved in the USA.
- Scott
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