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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by TriedEveryMedication on April 7, 2016, at 18:29:07
https://en.wikipedia.org/wiki/NSI-189
It supposedly triggers neuron growth in the hippocampus. It seems to be hot in certain internet circles.
Anyone try it? good/bad?
I just got my hands on some. I'm going to give a 6 week trial.
Posted by Samuel Morgan on April 7, 2016, at 23:53:10
In reply to Has anyone tried the novel antidepressant NSI-189?, posted by TriedEveryMedication on April 7, 2016, at 18:29:07
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Posted by swim on April 8, 2016, at 5:10:42
In reply to Has anyone tried the novel antidepressant NSI-189?, posted by TriedEveryMedication on April 7, 2016, at 18:29:07
Hi!
I have just ordered it from a Longcity member, should arrive during next week, i'll let you know how it goes, but at the moment i'll try to fix my Periodic Limb Movement Disorder and Restless leg Syndrome to get some good night sleep, maybe this will do the trick.
The NSI-89 is my next back-up plan if the drugs for the above mentioned disorders does not work. I feel so bad right now, just stopped Nardil which pooped out and i think it was actually for symptom management and the real case might be the sleep disorder(s) resulting in sleep deprivation, i so want to hope so, i need something to work yesterday, i feel soooooooooo bad, i count minutes as they go by and need to give at least a month for every drug .. it seems like an endless road
main complaint: treatment resistant depression
Posted by Lamdage22 on April 8, 2016, at 7:27:34
In reply to Re: Has anyone tried the novel antidepressant NSI-189?, posted by swim on April 8, 2016, at 5:10:42
i am sorry that you are feeling this way swim.
Do you have enough concentration to read or watch a movie?
Posted by TriedEveryMedication on April 8, 2016, at 8:56:36
In reply to Re: Has anyone tried the novel antidepressant NSI-189?, posted by swim on April 8, 2016, at 5:10:42
> Hi!
>
> I have just ordered it from a Longcity member, should arrive during next week, i'll let you know how it goes, but at the moment i'll try to fix my Periodic Limb Movement Disorder and Restless leg Syndrome to get some good night sleep, maybe this will do the trick.
>
> The NSI-89 is my next back-up plan if the drugs for the above mentioned disorders does not work. I feel so bad right now, just stopped Nardil which pooped out and i think it was actually for symptom management and the real case might be the sleep disorder(s) resulting in sleep deprivation, i so want to hope so, i need something to work yesterday, i feel soooooooooo bad, i count minutes as they go by and need to give at least a month for every drug .. it seems like an endless road
>
> main complaint: treatment resistant depressionSorry you feel so bad. Must be awful.
I got mine from a Longecity member, too. Took my first dose, made me kind of spacey and lethargic. having a tough time typing on it. probably not an indication of anything. I'll report back after a couple of days.
Posted by Lamdage22 on April 8, 2016, at 14:08:59
In reply to Re: Has anyone tried the novel antidepressant NSI-189?, posted by TriedEveryMedication on April 8, 2016, at 8:56:36
You guys are the first ones i meet who are doing this group buy thing outside of Longecity.
My chemistry teacher told me its risky.
Be safe.
Posted by TriedEveryMedication on April 8, 2016, at 14:27:57
In reply to Re: Has anyone tried the novel antidepressant NSI-189?, posted by Lamdage22 on April 8, 2016, at 14:08:59
> You guys are the first ones i meet who are doing this group buy thing outside of Longecity.
>
> My chemistry teacher told me its risky.
>
> Be safe.People there have been doing gas chromatography tests on the batches coming from china. Some have been good and some have been bad.
Posted by TriedEveryMedication on April 22, 2016, at 1:47:04
In reply to Has anyone tried the novel antidepressant NSI-189?, posted by TriedEveryMedication on April 7, 2016, at 18:29:07
This is affecting me differently than anything else I've ever taken in the past 15 years.
With a couple minor exceptions, my depression is gone. Completely.
Here's the weird thing, though. I'm thinking about things differently. I'm less cynical. I think about other people's feelings more. It feels like my emotional intelligence has shot up.
This could all be placebo. I didn't get any placebo effects from anything else, though. Just disappointment. I really wasn't expecting much from this drug.
On the downside, I feel a bit lazy on this drug. I also now suddenly want to quit my job and just travel.
another weird thing - my vision, which used to be perfect but went to sh*t in my mid 40s has improved slightly.
Still having very vivid dreams on this stuff.
Not taking anything else currently.
And still nobody knows the MOA of this drug. If NeuralStem knows, they aren't disclosing it. It has no or very weak binding affinities for 900 known receptor types.
Posted by Horse on April 23, 2016, at 3:57:23
In reply to 2 weeks on NSI-189. Remarkable., posted by TriedEveryMedication on April 22, 2016, at 1:47:04
Interesting. May be of help with ptsd, so by extension, maybe stress disorders (some anxiety disorders) can be helped at a primary level.
Glad it's working for you! Btw, I'm curious it's available to purchase before there is a name even.
Best of luck!
Posted by TriedEveryMedication on April 23, 2016, at 13:10:05
In reply to Re: 2 weeks on NSI-189. Remarkable. » TriedEveryMedication, posted by Horse on April 23, 2016, at 3:57:23
> Interesting. May be of help with ptsd, so by extension, maybe stress disorders (some anxiety disorders) can be helped at a primary level.
>
> Glad it's working for you! Btw, I'm curious it's available to purchase before there is a name even.
>
> Best of luck!People on the longecity forum are getting it synthesized by 3rd party labs with group-buys. As soon as the CAS number for the chemical was published 3rd party labs were able to figure out how to make it.
Yeah, that sounds sketchy, but I had a friend who is a chemist at a big northern california biotech company run a sample of the batch I got through his Xray crystallography machine to check the structure. It is legit.
Reference gas chromatography results of the real stuff are floating around on the internet, too - this is a pretty easy test to have done on a batch and easy to compare to the reference results.
If anyone here does try to get some, please have it tested.
I'm trying not to get too excited about this drug. A couple things to give pause: The company took a hit when their alzheimer's drug nsi-556 failed in phase 2 tests. NSI-189 hasn't started phase III yet. Some of these novel ADs crash and burn in phase III after glowing phase II results. Also if this is such a big blockbuster, why hasn't some big pharma bought up this little company as per what usually happens.
It's also been speculated this availability of NSI-189 (before it's even been named as you noted) is one big unethical guerilla marketing campaign. (i.e. leak the drug to people who'll go to any length to find relief via the forums that cater to brain hackers). This seems a bit far-fetched and couple just as easily backfire, too... The only reason I might give this a second of thought is because the batch I got was 1) professionally packaged 2) pretty cheap 3) tested at such a high purity ... plus the vendor was cagey about the name of the supplier that made it (he might just want to protect his profits, though I can't see how he's making any money selling this for 40 bucks for a 2 month supply). But maybe with modern equipment, bootleg synthesis isn't hard or expensive. I don't know.
Posted by Horse on April 24, 2016, at 14:34:29
In reply to Re: 2 weeks on NSI-189. Remarkable. » Horse, posted by TriedEveryMedication on April 23, 2016, at 13:10:05
Fascinating. Of course I caution you but certainly wish you the best. Perhaps if this is not 'the' cure, it might be a helpful adjunct. I believe if science keeps plugging away. Would you keep us updated?
Posted by KattManDo on April 25, 2016, at 15:25:14
In reply to 2 weeks on NSI-189. Remarkable., posted by TriedEveryMedication on April 22, 2016, at 1:47:04
Hi.
I hope you're continuing to feel good on the NSI.
I completely understand why it makes sense to have reasonable expectations, but with that said I'm trying to buy some of this now. I can't figure out how to post on Longecity without paying for membership.
Could you possibly send along information with how to get into the group buy?
Also, no matter how trustworthy the seller is, I will feel compelled to get it independently tested. I have looked up "independent labs" and have found a list of them, but do I need to ask for a specific test? Can I send it to ANY lab? I'm worried I'll trigger some sort of investigation by sending it to a lab.
> This is affecting me differently than anything else I've ever taken in the past 15 years.
>
> With a couple minor exceptions, my depression is gone. Completely.
>
> Here's the weird thing, though. I'm thinking about things differently. I'm less cynical. I think about other people's feelings more. It feels like my emotional intelligence has shot up.
>
> This could all be placebo. I didn't get any placebo effects from anything else, though. Just disappointment. I really wasn't expecting much from this drug.
>
> On the downside, I feel a bit lazy on this drug. I also now suddenly want to quit my job and just travel.
>
> another weird thing - my vision, which used to be perfect but went to sh*t in my mid 40s has improved slightly.
>
> Still having very vivid dreams on this stuff.
>
> Not taking anything else currently.
>
> And still nobody knows the MOA of this drug. If NeuralStem knows, they aren't disclosing it. It has no or very weak binding affinities for 900 known receptor types.
Posted by TriedEveryMedication on April 25, 2016, at 16:19:52
In reply to Re: 2 weeks on NSI-189. Remarkable., posted by KattManDo on April 25, 2016, at 15:25:14
> Hi.
>
> I hope you're continuing to feel good on the NSI.
>
> I completely understand why it makes sense to have reasonable expectations, but with that said I'm trying to buy some of this now. I can't figure out how to post on Longecity without paying for membership.
>
> Could you possibly send along information with how to get into the group buy?
>
> Also, no matter how trustworthy the seller is, I will feel compelled to get it independently tested. I have looked up "independent labs" and have found a list of them, but do I need to ask for a specific test? Can I send it to ANY lab? I'm worried I'll trigger some sort of investigation by sending it to a lab.
>gas chromatography test for composition and purity; nuclear magnetic resonance for structure. you're probably looking at $60-200 for the nmr test. Some really simple chem 101 tests you can do at home, too like melting point and figuring out the molar mass and comparing it to the published data.
here is some data on it that might be helpful for the lab.
http://www.biovision.com/manuals/2552.pdf (I believe biovision is Neuralstem's supplier. That name shows up in Neuralstem patent docs)didn't realize longecity charges now! When I signed up years ago it was free. I don't know if there are any more group buys, but there are at least two people on longecity that sell it. One has a website that sells other RCs, the other guy just deals via pms and is about 1/2 the price of the guy with the website. I got it from the guy who deals via PMs. Check the last 10 pages of the 140-page thread on NSI there and you'll find him. There's a thread on sources there, too. Sorry for being cryptic but I'm not sure if we're allowed to discuss sources here for things that are not FDA approved drugs and clear patent violators.
Posted by phidippus on May 6, 2016, at 6:06:10
In reply to 2 weeks on NSI-189. Remarkable., posted by TriedEveryMedication on April 22, 2016, at 1:47:04
How did you get on this?
Eric
This is the end of the thread.
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