![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by SLS on July 29, 2015, at 9:37:34
Can anyone comment on the use of Resveratrol? I am being treated for bipolar depression.
Technically, I would like to increase my levels of intracellular cAMP by inhibiting PDE4. Resveratrol is supposed to do this.
Thanks for any input.
- Scott
Posted by linkadge on July 29, 2015, at 19:56:58
In reply to Resveratrol?, posted by SLS on July 29, 2015, at 9:37:34
Hi SLS,
One thing that really helps me are Cocoa Nibs. This is essentially pure unprocessed cocoa pieces right out of the shell.
I put a link below to product I eat. You basically just put them in your mouth and chew. Its a bit bitter, but not bad.
The reason I mention, is because cocoa is a decent source of resveratrol as well as beta carbolines and epicatechin. The latter of which (like resveratrol) has effects on both monoamine reuptake and monoamine oxidase. The effects of some of these superfoods go beyond monoamines. Some of them have anti-inflammatory effects, effects on CAMP, PDE, PPAR (antidiabetic effects), GSK3, sirtuin (longevity) etc.
I would say that one mouthful of cocoa nibs feels like about 10-20mg of nortriptyline minus side effects. Give it a try, but take it slow, they can be stimulating!
I don't work for the company, and you know me, I have tried everything and generally only report on the best.
Linkadge
https://well.ca/products/organic-traditions-cacao-nibs_99791.html?gclid=COv-lMPRgccCFQuQaQod6Q8AFw
Posted by linkadge on July 29, 2015, at 19:58:28
In reply to Re: Resveratrol?, posted by linkadge on July 29, 2015, at 19:56:58
Oh, and I forgot to mention, cocoa also has effects on anandamide reuptake and hydrolysis.
Linkadge
Posted by SLS on July 29, 2015, at 21:58:02
In reply to Re: Resveratrol?, posted by linkadge on July 29, 2015, at 19:56:58
Posted by Lamdage22 on July 30, 2015, at 3:54:21
In reply to Resveratrol? - Thanks, Linkadge - Means alot :-) (nm) » linkadge, posted by SLS on July 29, 2015, at 21:58:02
let us know how dou do if you try.
Posted by phidippus on August 5, 2015, at 11:38:52
In reply to Resveratrol?, posted by SLS on July 29, 2015, at 9:37:34
http://www.ncbi.nlm.nih.gov/pubmed/24717328
Eric
Posted by SLS on August 9, 2015, at 8:09:03
In reply to Re: Resveratrol? » SLS, posted by phidippus on August 5, 2015, at 11:38:52
> http://www.ncbi.nlm.nih.gov/pubmed/24717328
>
> EricThanks, Eric.
- Scott
Posted by former poster on August 14, 2015, at 10:34:55
In reply to Resveratrol?, posted by SLS on July 29, 2015, at 9:37:34
I like Resveratrol. Seems to give overall benefits in body, brain and mood. However it gives me extreme insomnia.
Posted by SLS on January 10, 2016, at 23:52:16
In reply to Resveratrol?, posted by SLS on July 29, 2015, at 9:37:34
My thoughts regarding resveratrol are not unique.
PDE4 inhibition -> cAMP increase -> second messenger cascade -> BDNF increase -> hippocampal neurogenesis.
http://www.ncbi.nlm.nih.gov/pubmed/24717328
Resveratrol might best be used in conjunction with drugs that exert antidepressant effects. Desipramine maybe? Beta-adrenergic receptors are involved according to one study.
I'm going to try it. I just took my first dose.
- Scott
This is the end of the thread.
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.