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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by TriedEveryMedication on November 1, 2015, at 9:30:34
Currently taking 5mg Brintillex and 10mg of desipramine. I'm taking the desipramine for attentional and motivational problems.
When I first tried desipramine years ago, I took it at bed, and it would knock me out the entire night and I would wake up feeling very refreshed.
At some point, something changed.
Desipramine now wakes me up, (WIDE awake) around 3am, no matter when I take it. Before bed, in the morning... hell last night I set an alarm at 2am, and took it then, went back to sleep and BOOM - wide awake at 3am.
This happens even when I take desipramine by itself, so I'm pretty sure the brintellix has nothing to do with it. Only mentioned it because I'm taking it too
I've tried trazadone and ambien - they sort of work to keep me asleep, but they also completely defeat any benefits I get out of desipramine. Feel like a space cadet the next day after a night of either of those.
Any ideas?
Posted by SLS on November 1, 2015, at 13:08:32
In reply to Need ideas on beating desipramine insomnia, posted by TriedEveryMedication on November 1, 2015, at 9:30:34
How much desipramine were you taking last time?
How long have you been taking it at 10 mg/day this time?
- Scott
Posted by rjlockhart37 on November 1, 2015, at 13:14:05
In reply to Need ideas on beating desipramine insomnia, posted by TriedEveryMedication on November 1, 2015, at 9:30:34
one to lower the dose, or ask about a beta blocker ......because those block norepheinerine.....which desipraamine blocks the reuptake and increaess its levels ....
SNRI's are known to be activating, but they can also keep you over alert when it's not needed......
that or you can swtich to effexor
Posted by Lou Pilder on November 1, 2015, at 14:35:30
In reply to Need ideas on beating desipramine insomnia, posted by TriedEveryMedication on November 1, 2015, at 9:30:34
The taking of the drugs together could lead to your death. This is all because whoever prescribed these drugs to you gave you two drugs that could increase exponentially serotonin to cause coma and death. And all the while you are led to believe by people here that taking these drugs is supportive because Mr. Hsiung is allowing you to post that you are taking the drugs without him interceding to warn readers that serotonin syndrome could kill you from these drugs being taken together for he wants readers to trust him in what he is doing here.
You can stop this combination of drugs to save your life but you could have addiction and fall into a suicidal vortex that could compel you to kill yourself and/or others. And worse, others could encourage you here to take more drugs that could increase the possibility of death exponentially. And worse, you could be swayed to ignore me by the posts here inflicting harm against me going unsanctioned by Mr. Hsiung and if he is delighting at my suffering, laughing at me, just remember who is delighted and laughs when death has its victory by these drugs.
Lou
Posted by Lou Pilder on November 1, 2015, at 15:34:44
In reply to Lou's urgent plea- » TriedEveryMedication, posted by Lou Pilder on November 1, 2015, at 14:35:30
> The taking of the drugs together could lead to your death. This is all because whoever prescribed these drugs to you gave you two drugs that could increase exponentially serotonin to cause coma and death. And all the while you are led to believe by people here that taking these drugs is supportive because Mr. Hsiung is allowing you to post that you are taking the drugs without him interceding to warn readers that serotonin syndrome could kill you from these drugs being taken together for he wants readers to trust him in what he is doing here.
> You can stop this combination of drugs to save your life but you could have addiction and fall into a suicidal vortex that could compel you to kill yourself and/or others. And worse, others could encourage you here to take more drugs that could increase the possibility of death exponentially. And worse, you could be swayed to ignore me by the posts here inflicting harm against me going unsanctioned by Mr. Hsiung and if he is delighting at my suffering, laughing at me, just remember who is delighted and laughs when death has its victory by these drugs.
> LouFriends,
Who is allowed to inflict harm against me by Mr. Hsiung allowing the defamation against me to stand? And to whom is the arm of death reaching to here? Mr. Hsiung admits that by not him sanctioning the defamation against me here, that harm could come to me. But it is much worse than that. For he can not sanction the anti-Semitism here that could also cause harm to me as a Jew here. This then is a combination of hate allowed to inflict harm exponentially to me which decreases the respect, regard and confidence in which I am held and can induce hostile and disagreeable opinions and feelings against me here. This could cause you to see that I can be used as an open target of hate here that is not something new, but those that ignore me could lose their life because it could be too late for them to live as they could be killed by the drugs before they find in the drugs what they are told that they could find and death finds them.
Posted by TriedEveryMedication on November 1, 2015, at 18:12:35
In reply to Re: Need ideas on beating desipramine insomnia » TriedEveryMedication, posted by SLS on November 1, 2015, at 13:08:32
> How much desipramine were you taking last time?
>
> How long have you been taking it at 10 mg/day this time?
>
>
> - ScottHi Scott,
Long ago when I was taking desip and it was not giving me insomnia, I believe my dose was about 25mg. Longest I've ever taken it was about 3 months. Big time gaps between when I've used it and not. It's the only thing that seems to help my ADD, though.
after the insomnia started, I played around with the dose, from 10mg-75mg.
Currently, I've been taking 10mg for a couple of days now.
Posted by Christ_empowered on November 3, 2015, at 13:43:08
In reply to Need ideas on beating desipramine insomnia, posted by TriedEveryMedication on November 1, 2015, at 9:30:34
If Ambien causes problems, I would imagine the other z hypnotics would, too. Still... another z drug, like sonata maybe, or maybe an old school benzo-type sleeping pill (Restoril works well for a lot of people, for instance).
That's all I can think of, unless you want to try supplements.
Posted by Hugh on November 3, 2015, at 18:39:12
In reply to Need ideas on beating desipramine insomnia, posted by TriedEveryMedication on November 1, 2015, at 9:30:34
Have you ever tried amitriptyline? It, like desipramine, is sometimes prescribed for ADHD. And it's sometimes prescribed for insomnia.
One of the best things I've ever tried for insomnia -- and I've tried benzos, Ambien, trazodone, etc. -- is unmodified potato starch.
Posted by TriedEveryMedication on November 3, 2015, at 22:28:50
In reply to Re: Need ideas on beating desipramine insomnia, posted by Hugh on November 3, 2015, at 18:39:12
> Have you ever tried amitriptyline? It, like desipramine, is sometimes prescribed for ADHD. And it's sometimes prescribed for insomnia.
>
> One of the best things I've ever tried for insomnia -- and I've tried benzos, Ambien, trazodone, etc. -- is unmodified potato starch.
>
> https://mrheisenbug.wordpress.com/2014/08/06/why-resistant-starch-prebiotic-fiber-improve-sleep-and-dreaming/I've tried amitriptyline plus a few other TCAs. despiramine is really the only one that works for me consistently.
desip's binding affinity for the norepi transport is about 20 times greater than amitriptyline. I believe the norepi action is what improves my focus. (oddly enough, strattera doesn't work for me, so there is something else that desip is ticking, too)
This is the end of the thread.
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