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Dr. Bob is Robert Hsiung, MD,
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Posted by phidippus on August 28, 2015, at 14:10:28
A new study links family problems and other early life adversity to variation in brain structure in late adolescence and an increased risk for depression and anxiety among boys.
"The translational implications of this prospective study suggest the importance of interventions and policies for reducing mental health problems and enhancing at-risk children's well-being," Edward Barker, PhD, from the Department of Psychology, Institute of Psychiatry, King's College London, United Kingdom, told Medscape Medical News.
Dr Barker, first author Sarah Jensen, MSc, from King's College London, and colleagues describe their research online August 17 in JAMA Pediatrics.
The researchers studied the effects of early-life adversity, such as interpersonal loss, family instability, and abuse toward the child and/or mother, experienced within the first 6 years of life, and child internalizing symptoms (ie, depression, anxiety) on cortical gray matter volume at age 18 to 21 years.
Participants included 494 mother-son pairs from the Avon Longitudinal Study of Parents and Children (ALSPAC). The mothers reported on family adversities encountered by their sons through age 6. They also provided information on internalizing symptoms when their sons were aged 7, 10, and 13 years. In late adolescence, the boys underwent MRI.
The researchers found that early adversity predicted lower GM volumes in the anterior cingulate cortex (β = 0.18; P = .01), which is involved in emotion, decision-making, and empathy, and greater GM volume in the precuneus (β = 0.18; P = .009), involved in episodic memory, in adolescence.
Child internalizing symptoms were associated with lower GM volume in the right superior frontal gyrus (β = 0.20; P = .002).
Early adversity was also associated with higher levels of internalizing symptoms (β = .37; P < .001), which, in turn, were associated with lower superior frontal gyrus volume (β = 0.08; P = .02), the researchers say.
"Early adversity was related to variation in brain structure both directly and via increased levels of internalizing symptoms," they note in their article.
The results "confirm what we hypothesized that variation in brain structure that associates with symptoms of depression does so (in part) through the early experience of adversity," Dr Barker told Medscape Medical News. "In other words, early adversity increases later symptoms of depression/anxiety, which, in turn, can associate with variation in cortical structure. Although this idea has been around for a while, we were the first to examine it with a prospective longitudinal birth cohort."
"Community agencies (eg, schools, churches, healthcare settings) can provide parents with information that not only does adversity negatively impact children's development but also a reduction in adversity may have positive effects on children's development," Dr Barker said.
"In addition, efficacious preventive interventions could be made available. Policy makers, in particular, may be helpful promoting early preventive intervention as a means of enhancing outcomes for disadvantaged children," he said.
The study had no commercial funding, and the authors have disclosed no relevant financial relationships.
JAMA Pediatr. Published online August 17, 2015. Abstract
Posted by SLS on August 29, 2015, at 4:17:14
In reply to Early-Life Adversity Tied to Brain Structure, Depr, posted by phidippus on August 28, 2015, at 14:10:28
The link between childhood adversity and the increased risk of psychobiological mental illness has been known for quite some time. Developmental or chronic childhood PTSD almost guarantee an untoward outcome. What is interesting is that neglect can be as big a contributor to childhood adversity as is physical or emotional abuse. I think that there is also a reduction in hippocampal and white matter volume involved here, but I might be misremembering this.
Perhaps a few more scientific articles and books can make this information accessible to the general public. It might make a difference.
- Scott
Posted by porkpiehat on September 3, 2015, at 9:21:10
In reply to Re: Early-Life Adversity Tied to Brain Structure, Depr, posted by SLS on August 29, 2015, at 4:17:14
I wonder if this has any repercussions in terms of treatment. This describes me perfectly and I've been in therapy for 20 years and I honestly feel like I'm wasting my time.
Posted by SLS on September 3, 2015, at 12:02:29
In reply to Re: Early-Life Adversity Tied to Brain Structure, Depr, posted by porkpiehat on September 3, 2015, at 9:21:10
> I wonder if this has any repercussions in terms of treatment. This describes me perfectly and I've been in therapy for 20 years and I honestly feel like I'm wasting my time.
Because of my childhood history of neglect, abuse, and bullying, my doctor dreamed up using high dosages of prazosin to aid in treating my bipolar depression. To my great surprise, it has produced a significant improvement. I take 30 mg/day (10 mg t.i.d.).
- Scott
Posted by porkpiehat on September 3, 2015, at 19:16:57
In reply to Re: Early-Life Adversity Tied to Brain Structure, Depr » porkpiehat, posted by SLS on September 3, 2015, at 12:02:29
> Because of my childhood history of neglect, abuse, and bullying, my doctor dreamed up using high dosages of prazosin to aid in treating my bipolar depression. To my great surprise, it has produced a significant improvement. I take 30 mg/day (10 mg t.i.d.).
>
>
> - Scott
My doc prescribed Prazosin at 2mgs or so, thinking that I would have fewer night terrors and therefore feel better during the day. I only tried it a few times as it sapped my motivation a little and made me congested. I could have given it a better trial if I thought it was going somewhere.How is this affecting your blood pressure/energy levels? and how would you described its therapeutic effect. I'm very interested in this.
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