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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Horse on August 1, 2015, at 18:15:19
My doc increased my lexapro from 20-30 mg because anxiety and panic attacks have returned after a year.
Among his thoughts was that if this didn't work, we could switch to another AD, perhaps Brintellix.
Any experience here with it? I can't crunch the numbers, so any science-heads know why it might work for anxiety over another AD?
Posted by SLS on August 1, 2015, at 19:03:26
In reply to Brintellix, posted by Horse on August 1, 2015, at 18:15:19
> My doc increased my lexapro from 20-30 mg because anxiety and panic attacks have returned after a year.
>
> Among his thoughts was that if this didn't work, we could switch to another AD, perhaps Brintellix.
>
> Any experience here with it? I can't crunch the numbers, so any science-heads know why it might work for anxiety over another AD?Try to get the attention of Phidippus (Eric). He is currently taking Brintellix 40 mg/day. He really likes it. I believe he has OCD to contend with. His post:
http://www.dr-bob.org/babble/psycho/20150512/msgs/1080823.html
- Scott
Posted by Horse on August 1, 2015, at 19:08:46
In reply to Re: Brintellix » Horse, posted by SLS on August 1, 2015, at 19:03:26
Thanks! Maybe he'll see the subject line.
Posted by Phillipa on August 2, 2015, at 9:39:18
In reply to Re: Brintellix, posted by Horse on August 1, 2015, at 19:08:46
He's on my friends list on facebook. Phillipa
Posted by Horse on August 4, 2015, at 19:13:04
In reply to Re: Brintellix » Horse, posted by Phillipa on August 2, 2015, at 9:39:18
I don't use fb.
Posted by phidippus on August 5, 2015, at 10:04:20
In reply to Brintellix, posted by Horse on August 1, 2015, at 18:15:19
Brintellix is fantastic for anxiety at higher doses-twice those prescribed for depression. 20 mg is the max dose, but I take 40 mg and have experienced a strong anxiolytic effect.
Brintellix acts as a 5ht1a receptor agonist, a 5ht1d antagonist and a 5ht3a antagonistm-all of these mechanisms deliver an anxiolytic effect.
Eric
Posted by Horse on August 5, 2015, at 10:36:41
In reply to Re: Brintellix » Horse, posted by phidippus on August 5, 2015, at 10:04:20
Thanks Eric. I'm switching today. Fingers crossed.
So not mania inducing?
Posted by phidippus on August 5, 2015, at 11:48:22
In reply to Re: Brintellix, posted by Horse on August 5, 2015, at 10:36:41
I haven't experienced any manic switching.
Eric
Posted by Horse on August 5, 2015, at 14:33:18
In reply to Re: Brintellix » Horse, posted by phidippus on August 5, 2015, at 11:48:22
> I haven't experienced any manic switching.
>
> EricThat's good. Saphris induced a strong hypomania. I recall both have some 5-ht7 action. Which may not have anything to do with Saphris' affect.
Well, I start tonight. Thanks Eric and best to you.
Posted by Horse on August 7, 2015, at 1:33:38
In reply to Re: Brintellix » phidippus, posted by Horse on August 5, 2015, at 14:33:18
I misremembered. It was Latuda I was thinking about. It did not cause mania as did Saphris. It produced agitation.
Thanks all for input.
> > I haven't experienced any manic switching.
> >
> > Eric
>
> That's good. Saphris induced a strong hypomania. I recall both have some 5-ht7 action. Which may not have anything to do with Saphris' affect.
>
> Well, I start tonight. Thanks Eric and best to you.
>
Posted by SLS on August 7, 2015, at 6:15:58
In reply to Re: Brintellix, posted by Horse on August 7, 2015, at 1:33:38
> I misremembered. It was Latuda I was thinking about. It did not cause mania as did Saphris. It produced agitation.
Latuda treated me badly. It exacerbated my bipolar depression. I'm thinking that NE alpha-2 antagonism is responsible for this. Saphris demonstrated some transient antidepressant effects for me. Unfortunately, it stopped working. My friend gleaned a huge antidepressant effect from it. It doesn't surprise me that you became manic on it.
I wish you better luck with Brintellix.
- Scott
This is the end of the thread.
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