Psycho-Babble Medication Thread 1080525

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BDNF genotypes and response to different drugs

Posted by SLS on July 15, 2015, at 16:03:20

BDNF (brain-derived neurotrophic factor) is a growth hormones for neurons.

A recent study published in the Journal of Affective Disorders (April 2015) suggests that different genotypes coding for BDNF may help to determine drug choice in mood disorders. People with one type of BDNF respond better to SSRIs, while those with another type respond better to SNRIs and tricyclics. There is more work to be done to reproduce these findings. However, we are getting closer to biological tests to diagnose and determine treatments for people with mental illness.

Genotypes for the BDNF gene versus drug choice:

val66val = SSRI = 66% of people
val66met and met66met = SNRI; TCA = 33% of people

Previously, BDNF genotypes were associated with varying responses to ketamine.

val66val 65.5% = best response to ketamine
val66met 31.5% = intermediate response to ketamine
met66met 3.0% = poor-response to ketamine


- Scott

 

Sorry - BDNF genotypes percentage - not response

Posted by SLS on July 15, 2015, at 18:16:13

In reply to BDNF genotypes and response to different drugs, posted by SLS on July 15, 2015, at 16:03:20

I apologize.

My statistics are confusing here. The percentage of people I quoted was the frequency of the genotype seen in the general population - not the percentage of responders.

val66val = 66% of population
val66met = 31% of population
met66met = 3% of population

-----------------------------------

Genotypes for the BDNF gene versus drug choice:

val66val = SSRI
val66met = SNRI; TCA
met66met = SNRI; TCA

-----------------------------------

Previously, BDNF genotypes were associated with varying responses to ketamine:

val66val = best response to ketamine
val66met = intermediate response to ketamine
met66met = poor-response to ketamine

-----------------------------------


- Scott

 

Re: Sorry - BDNF genotypes percentage - not response

Posted by Linkadge on July 18, 2015, at 17:07:34

In reply to Sorry - BDNF genotypes percentage - not response, posted by SLS on July 15, 2015, at 18:16:13

Interesting. I guess I can look up the effector these genes on BDNF function.

I tend to feel better on SNRi's and TCas. SSRIs worked better when I was younger, but my depression in later years has involved much more energy loss and apathy.

There is no logical reason that Effexor should work differently than an Ssri in low doses, but it seems to for me.


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