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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 11 of 11. This is the beginning of the thread.
Posted by Lamdage22 on February 17, 2015, at 1:58:41
http://www.naurex.com/wp-content/uploads/2015/01/Naurex-NRX-1074-Phase-2-Data-PR_FINAL_012615.pdf
Check this out. They got a name for their lead compound.
The most exiting drug development for me. I follow whats going on on a regular basis.
Prolly will hit the market (if successful) this decade.
Posted by ed_uk2010 on February 17, 2015, at 18:42:17
In reply to Naurexs Glyx-13 ('Rapastinel') and NRX-1074, posted by Lamdage22 on February 17, 2015, at 1:58:41
Very interesting and promising.
Thanks for posting.
Posted by Lamdage22 on February 18, 2015, at 12:43:06
In reply to Re: Naurexs Glyx-13 ('Rapastinel') and NRX-1074, posted by ed_uk2010 on February 17, 2015, at 18:42:17
No problem. I will continue to post.
Posted by b2chica on February 27, 2015, at 16:47:21
In reply to Re: Naurexs Glyx-13 ('Rapastinel') and NRX-1074, posted by Lamdage22 on February 18, 2015, at 12:43:06
I needed some hope today. Thanks!
Posted by SLS on March 11, 2015, at 6:41:13
In reply to Re: Naurexs Glyx-13 ('Rapastinel') and NRX-1074, posted by b2chica on February 27, 2015, at 16:47:21
> I needed some hope today. Thanks!
Glyx-13 is administered i.v.
NRX-1074 is administered orally
More hope:hydroxynoketamine (HNK) - ketamine metabolite that does NOT bind to NMDA receptors. It is taken orally and does not produce the dissociative or pyschotic side effects of ketamine.
http://news.doximity.com/entries/1461865?_ref=email&account_id=230135
- Scott
Posted by Lamdage22 on March 11, 2015, at 7:19:58
In reply to Re: Naurexs Glyx-13 ('Rapastinel') and NRX-1074, posted by SLS on March 11, 2015, at 6:41:13
How long until it reaches patients, scott?
Posted by SLS on March 11, 2015, at 11:41:42
In reply to Re: Naurexs Glyx-13 ('Rapastinel') and NRX-1074, posted by Lamdage22 on March 11, 2015, at 7:19:58
> How long until it reaches patients, scott?
I don't know. :-(
- Scott
Posted by Lamdage22 on March 16, 2015, at 10:51:29
In reply to Re: Naurexs Glyx-13 ('Rapastinel') and NRX-1074, posted by SLS on March 11, 2015, at 6:41:13
Is HNK dopaminergic?
Could it be combined with Rapastinel for ultimate efficacy?
Posted by Lamdage22 on March 16, 2015, at 11:14:05
In reply to @ScottRe: Naurexs Glyx-13 ('Rapastinel') and NRX-1074, posted by Lamdage22 on March 16, 2015, at 10:51:29
Scott,
can you post a few links?
Is HNK in clinical trials??
Posted by SLS on March 16, 2015, at 22:08:22
In reply to @ScottRe: Naurexs Glyx-13 ('Rapastinel') and NRX-1074, posted by Lamdage22 on March 16, 2015, at 10:51:29
> Is HNK dopaminergic?
That's a difficult question to answer. Even if HNK (hydroxynorketamine) does not act directly on DA neurons, it may lead to an increase in DA activity secondarily downstream. I don't really know.
> Could it be combined with Rapastinel for ultimate efficacy?I'll have to review the properties this drug possesses. The recent animal data, indicates that administration of HNK should be sufficient.
http://www.sciencedaily.com/releases/2014/06/140617093820.htm
Apparently, HNK is not yet in clinical trials. One would have to rely on animal data indicating antidepressant activity.
Check out the action of HNK to reduce D-serine in degenerative disorders like Alzheimers and Parkinsons.
- Scott
Posted by Lamdage22 on April 21, 2015, at 0:00:05
In reply to Re: @ScottRe: Naurexs Glyx-13 ('Rapastinel') and NRX-1074 » Lamdage22, posted by SLS on March 16, 2015, at 22:08:22
I hope this stuff comes out soon.
I could really use it
This is the end of the thread.
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