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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by Hello123 on September 12, 2014, at 16:41:12
I've read many articles on Pubmed about how 5HT aka serotonin indirectly effects the release of other neurotransmitters and hormones. such as. when Serotonin stimulates the 5htc receptor, dopamine release is inhibited. and many people report feeling less emotional a out things when SSRI's increase their Serotonin levels. and i know from experience with meds that increase the levels of neurotransmitters that SSRI's indirectly decrease(like Aderall increasing Dopamine) that these meds make yiu feel more emotional about life.
so i get the idea that Serotonins main role is to modulate the increase/decrease of other neurotransmitters. and that it dossnt directly effect emotions by stimulating Serotonin receptors.
what do others think?
Posted by Hello123 on September 12, 2014, at 21:28:32
In reply to Do u think 5HT directly effects emotions, posted by Hello123 on September 12, 2014, at 16:41:12
Yahh i know this is kinda technical. but its just something I've been wondering about.
Posted by rjlockhart37 on September 14, 2014, at 23:05:25
In reply to Do u think 5HT directly effects emotions, posted by Hello123 on September 12, 2014, at 16:41:12
i don't have the sources with me but serotonin with some paticular antidepressants can reduce emotion and cause apathy......
which MDMA is the opposite, it directly stimulates serotonin like amphetamine stimulates dopamine, same thing, just a diffrent nuerotransmitter target.....and usally extasy causes feelings of bliss and contentment....until it wears off....
taking 5HTP can reduce some feelings, i've taken it before and it ... does produce serotonin but it's not in a euphoric way.....never take that with Prozac or any serotonin antidepressant....serotonin syndrome
r
Posted by Lamdage22 on October 7, 2014, at 17:32:39
In reply to Re: Do u think 5HT directly effects emotions, posted by rjlockhart37 on September 14, 2014, at 23:05:25
Well i think serotonin will slowly loose its status as "the ultimate antidepressant target".
I think it is pretty overrated.
For me SSRI type drugs cause dulling of emotions. But it is not my goal to have more emotions than i do now.
Posted by phidippus on October 20, 2014, at 17:53:52
In reply to Re: Do u think 5HT directly effects emotions, posted by Lamdage22 on October 7, 2014, at 17:32:39
I think the futuire lies in targeting certain 5ht receptors.
Eric
Posted by Lamdage22 on October 24, 2014, at 11:30:56
In reply to Re: Do u think 5HT directly effects emotions » Lamdage22, posted by phidippus on October 20, 2014, at 17:53:52
> I think the futuire lies in targeting certain 5ht receptors.
>
> EricI think its nmda receptors and neurogenesis.
5ht is really boring and old and -for me- useless.
Posted by phidippus on October 31, 2014, at 18:26:25
In reply to Re: Do u think 5HT directly effects emotions, posted by Lamdage22 on October 24, 2014, at 11:30:56
I think we're finding out more and more each day that different 5ht receptors effect the brain in different ways than we thought. Targeting certain 5ht receptors for agonism or antagonism can really change the effect of a drug. The newest antidepressants and atypical antipsychotics are agonizing and antagonizing many different 5ht receptors for therapeutic benefit.
NMDA is complex stuff and the therapeutic benefits of antagonizing or agonizing NMDA receptors remains unclear. We know that antagonizing NMDA can lead to unwanted effects such as hallucinations and depersonalized states. PCP, Ketamine, dextromathorphan and ethanol can all cause hallucinations and depersonalized states. Even NMDA antagonists we have developed for clinical use have these undesirable side effects, like Memantine. Do the benefits of NMDA outweigh the risk? Ketamine supposedly delivers fast relief from depression, but its effects last only a day or two and there are considerable side effects. Is anyone developing an NMDA antidepressant without the side effects? AstraZeneca was developing Lanicemine, but that ended in 2013. AZD6765, an NMDA receptor blocker is another being developed. GLYX-13 is being developed for IV administration and there is evidence to suggest that the NMDA receptor ligands can demonstrate rapid antidepressant effects. NMDA is an exciting thing to explore, but we still don't understand it.
Eric
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