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Dr. Bob is Robert Hsiung, MD,
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Posted by uncouth on March 10, 2014, at 13:55:15
Hi all,
Has anyone had any experience or done any research on the use of oxytocin intranasal spray?
I am BP2, and have addictive/compulsive tendencies that tend to wax and wane, some low grade anxiety but significant issues with the motivation and reward of socialization. I just prefer to be by myself, but I "really" don't prefer it. I have some friends, but very limited romantic relationships or much desire to reach out and socialize with new people or groups even if it would give the opportunity for sexual encounters. I do not feel "social anxiety" in the physical sense, per se, it's more like just total disinterest due to either mental fears, learned behavior, or, quite frankly, my judgement and dislike of other people, and my fear of receiving that in return.
I'm just not a very open person despite having the actual ability to socialize and talk just fine! Something is off though :(
HAs anyone used oxytocin -- for anything??? Details please? What effect on mood, socialization, motivation, mood stability, -- anything. I also hear it is being trailed for addiction and compulsive issues.
I do -- and perhaps this is an important signal -- I LOVE massage. Not sexual massage, just being touched in a clinical, massage setting. I think i'd prefer getting a really good massage to sex, to be honest, unless I was really really really into the person and had feelings for them.
Posted by Tomatheus on March 10, 2014, at 16:12:34
In reply to Oxytocin intranasally???, posted by uncouth on March 10, 2014, at 13:55:15
Uncouth,
I haven't tried intranasal oxytocin, but I described my experience with trying a sublingual form of oxytocin here:
http://www.dr-bob.org/babble/alter/20120530/msgs/1023281.html
I also seem to remember the sublingual oxytocin supplement that I took becoming less effective over the course of the few days I spent taking the supplement, but maybe I'm not remembering things correctly. Of course, I only took sublingual oxytocin for a few days, which probably doesn't give you the kind of information that you're looking for as far as a full trial is concerned, but hopefully you'll find what I wrote to be better than nothing.
Alternatively, if you're looking to increase oxytocin levels via different means, taking vitamin D might be an option. According to Patrick & Ames (2014), "genes encoding the oxytocin-neurophysin I preproprotein, the oxytocin receptor, and the arginine vasopressin receptor contain [vitamin D response elements] for activation." Put more simply, the Patrick & Ames (2014) article explained that vitamin D directly controls oxytocin, wrote John Cannell, M.D., in a blog (https://www.vitamindcouncil.org/blog/new-study-finds-vitamin-d-regulates-three-genes-involved-in-autism/).
My understanding is that there are some studies that have found vitamin D to be lower in patients with depression than in controls and that low levels of the vitamin might conceivably explain many of the biomarkers that have been found to be associated with clinical depression. Also from what I understand, studies examining vitamin D as a treatment for depression have yielded mixed results, although the only placebo-controlled study I'm aware of that lasted a year (Jorde et al., 2008) did have a positive finding (supplementation was significantly more effective than placebo).
Just some things to think about.
Tomatheus
==
REFERENCES
Jorde, R., Sneve, M., Figenschau, Y., Svartberg, J., & Waterloo, K. (2008). Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: Randomized double blind trial. Journal of Internal Medicine, 264, 599-609. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/18793245
Patrick, R.P, & Ames, B.N. (2014). Vitamin D hormone regulates serotonin synthesis. Part 1: Relevance for autism. FASEB Journal, Feb. 20 [Epub ahead of print]. Abstract: http://www.ncbi.nlm.nih.gov/pubmed/24558199
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