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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 8 of 8. This is the beginning of the thread.
Posted by Jeroen on January 26, 2014, at 17:27:42
positive symptoms and not negative
which is very bad for everyone, that means anti depressant dont treat negative symptoms
Posted by SLS on January 26, 2014, at 18:30:44
In reply to nurse admits anti psychotics treat only pos sympto, posted by Jeroen on January 26, 2014, at 17:27:42
Do you have access to Saphris (asenapine) or Latuda (lurasidone)?
My impression of these drugs is that they both help with negative symptoms, although through different mechanisms. If you don't respond to one, you might respond to the other.
Did Seroquel help with negative symptoms, even if only temporarily?
What are your negative symptoms?
- Scott
Posted by Phillipa on January 26, 2014, at 21:13:36
In reply to Re: nurse admits anti psychotics treat only pos sympto » Jeroen, posted by SLS on January 26, 2014, at 18:30:44
Jeroen would your doc let you try either of thes meds? Phillipa
Posted by Jeroen on January 27, 2014, at 3:13:56
In reply to Re: nurse admits anti psychotics treat only pos sympto » Jeroen, posted by SLS on January 26, 2014, at 18:30:44
Seroquel is like a sleeping pill for my only : (
they wont give me Saphris
Posted by Christ_empowered on January 27, 2014, at 3:36:43
In reply to nurse admits anti psychotics treat only pos sympto, posted by Jeroen on January 26, 2014, at 17:27:42
I read somewhere that using Abilify AM and Remeron (mirazapine) PM helped improve negative symptoms and mood and anxiety. The combo also reduced akathisia.
Posted by poser938 on January 27, 2014, at 4:50:12
In reply to Re: nurse admits anti psychotics treat only pos sympto, posted by Christ_empowered on January 27, 2014, at 3:36:43
Cyproheptadine with its Serotonin antagonism has also been shown to help improve negative symptoms.
I hope this link works on regular computers. I'm on a tablet and some of my links are different.
http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2710.1999.00197.x/abstract
Summary
Objective: There is growing interest in investigating the role of 5-HT receptors in the physiopathology of schizophrenia in particular the negative symptoms. Indeed, newer atypical antipsychotics which interact with 5-HT receptors are more effective in the treatment of negative symptoms compared to typical neuroleptics. We undertook a trial to investigate whether the combination of haloperidol with cyproheptadine, a relatively safe serotonin-blocking agent was more effective than haloperidol alone.Methods: Thirty patients who met the DSM IV criteria for chronic schizophrenia completed the study. Patients were allocated in a random fashion, 15 each to haloperidol 30 mg/day plus cyproheptadine 24 mg/day and haloperidol 30 mg/day plus placebo.
Results: Although both protocols significantly decreased the positive and negative symptom score over the trial period, the combination of haloperidol and cyproheptadine showed significant superiority over haloperidol alone in the treatment of the negative symptoms.
Conclusion: Cyproheptadine is a relatively safe compound and may be of therapeutic benefit in treating negative symptoms of schizophrenia in combination with typical neuroleptics. However, a larger study to comfirm our results is warranted.
Posted by phidippus on January 27, 2014, at 19:48:11
In reply to nurse admits anti psychotics treat only pos sympto, posted by Jeroen on January 26, 2014, at 17:27:42
I wouldn't put much weight on the word of one nurse.
Eric
Posted by jono_in_adelaide on January 27, 2014, at 23:59:18
In reply to Re: nurse admits anti psychotics treat only pos sympto » Jeroen, posted by phidippus on January 27, 2014, at 19:48:11
I think the older neuroleptics like chlorpromazine, trifluroperazine and haloperidol only treated positive symptoms, but there is a fair swag of evidence that the newer atypical drugs do impact negative symptoms
I'd imagine adding an antidepressant would help as well
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