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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 3 of 3. This is the beginning of the thread.
Posted by doxogenic boy on September 25, 2013, at 16:39:11
Is neurogenesis in adult primates a myth? It says so in the article below. Have any of you heard of this before?
http://bipolarnews.org/?p=1949
Excerpt:
The Myth of Neurogenesis in Adult Primates Debunked
July 22, 2013 · Posted in Neurobiology
In a plenary lecture at the Collegium Internationale Neuro-Psychopharmacologicum (CINP) in Istanbul in 2012, Pasco Rakic, professor of neuroanatomy at Yale University, may have debunked a myth of modern medicine, one that we have cited in many previous BNNs. Despite what has been written by famous neuroscientists and published in the most prestigious journals, including Science, Cell, and PNAS, based on data in rodents, Rakic presented evidence that neurogenesis does not occur to any substantial extent in adult primates.
[...]
However, on the positive side, the mood stabilizers (lithium, lamotrigine, valproate, and carbamazepine) and some atypical antipsychotics prevent episodes and increase the neuroprotective factor BDNF, or brain-derived neurotrophic factor, which facilitates synaptogenesis and helps protect neurons. BDNF is produced in selected neurons in the brain and decreases with stress and affective episodes, further endangering neurons.
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See also my post about brain volume and antipsychotics:
http://www.dr-bob.org/babble/20130828/msgs/1051297.html- doxogenic
Posted by alexandra_k on September 25, 2013, at 19:10:56
In reply to The Myth of Neurogenesis?, posted by doxogenic boy on September 25, 2013, at 16:39:11
I'm not entirely sure...
I hear people can do surprisingly well on surprisingly little brain (e.g., after stroke). but it does depend on *which parts* they lost, rather.
New neurones is one thing...
New neural connections (e.g., dendrites, terminal branches) is something else...
More receptor sites is one thing...
Levels of neurotransmitter is another...We don't really know very much at all about any one of those. Even less about how one of those interacts with other aspects of that...
Brains go through 'proliferate and prune' cycles when we are very young. Growing lots of connections and then culling a lot of those connections. The culling part of the process seems every bit as important as the growing part of the process. Which is just to say that it isn't so much HOW MANY neurones or neural connections you have... But more something about the structural arrangement.
So...
I don't know what (if anything) to make of this finding (even if it is true)
Posted by doxogenic boy on September 26, 2013, at 7:35:45
In reply to Re: The Myth of Neurogenesis?, posted by alexandra_k on September 25, 2013, at 19:10:56
Thanks for your reply.
I think it is sensational if it is true that all the reasearch about neurogensis is wrong, but I am not sure I believe it at this stage.
- doxogenic
This is the end of the thread.
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