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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by g_g_g_unit on May 23, 2013, at 4:05:03
I've been taking 50mg of minocycline for the past two days alongside 40mg of Parnate.
I am not really sure what my psychiatrist's plans for Parnate are; he felt it was the best choice for my symptoms, but, even though I told him I'm extremely sensitive to meds, he has me dosing all 40mg before 3pm. This has been producing a combination of excessive apathy and/or agitation and overstimulation. I think he said he would like to exceed 60mg, so it's my hope that higher doses prove more anxiolytic (as I've read can paradoxically occur).
What's strange is that the minocycline seems to put a kind of cap on the excessive stimulation I experience in the 2-2.5 hour window after dosing, so things like reading and concentrating are easier. But whereas I usually fall into a slump once the immediate effects of Parnate wear off, I'm now very activated and agitated (in an unpleasant way) for the rest of the day.
I'm debating whether or not to try and ride the effect out, or dump the minocycline until I am (hopefully) stabilized on Parnate.
SLS, I believe you said in an earlier thread, that minocycline can produce activation/agitation at the beginning of treatment? Do you know how long this usually lasts for?
Posted by SLS on May 23, 2013, at 5:46:15
In reply to minocycline so far, posted by g_g_g_unit on May 23, 2013, at 4:05:03
Hi.
> I've been taking 50mg of minocycline for the past two days alongside 40mg of Parnate.
>
> I am not really sure what my psychiatrist's plans for Parnate are; he felt it was the best choice for my symptoms, but, even though I told him I'm extremely sensitive to meds, he has me dosing all 40mg before 3pm. This has been producing a combination of excessive apathy and/or agitation and overstimulation. I think he said he would like to exceed 60mg, so it's my hope that higher doses prove more anxiolytic (as I've read can paradoxically occur).Your doctor appears to have some experience with MAOIs. The 3pm thing is to help mitigate insomnia. 40 mg/day is the lowest dosage I would expect most people to respond to, even if they are sensitive to medication side effects.
> SLS, I believe you said in an earlier thread, that minocycline can produce activation/agitation at the beginning of treatment? Do you know how long this usually lasts for?
There really isn't enough experience with minocycline for various MI indications to make general statements about its psychotropic behaviors. However, from the few people I know who are taking it, the uncomfortable activation seems to dissipate in a week or less. You might need 100 - 200 mg/day of minocycline to fully benefit from it.
Good luck.
- Scott
Posted by g_g_g_unit on May 23, 2013, at 7:35:46
In reply to Re: minocycline so far » g_g_g_unit, posted by SLS on May 23, 2013, at 5:46:15
>
> There really isn't enough experience with minocycline for various MI indications to make general statements about its psychotropic behaviors. However, from the few people I know who are taking it, the uncomfortable activation seems to dissipate in a week or less. You might need 100 - 200 mg/day of minocycline to fully benefit from it.
>
> Good luck.
>
>
> - ScottThanks for your response. As tempting as it is to continue with minocycline, I'm thinking it might be prudent to discontinue it until I get a better sense of what Parnate's doing. I'm worried I won't be able to tease apart the activating effects of one versus the other.
Posted by Phillipa on May 23, 2013, at 9:39:35
In reply to Re: minocycline so far » SLS, posted by g_g_g_unit on May 23, 2013, at 7:35:46
A bit off topic but last summer was given minocycline for peri-oral dermatitis and had to discontinue after l day. The dizziness was bad. It can also cause a lupus like syndrome which take a year to go away after discontinuing. And also blackening of gums and some other body parts. I did not want to possibly raise my resistance to antibiotics should I need them at some time in the future. It was given instead of doxycycline as in the summer causes sunburn. I used clindymycin lotion and one other successfully on the skin as it worked. I personally would just look up the minocycline as an antibiotic first. Phillipa
Posted by SLS on May 23, 2013, at 10:05:47
In reply to Re: minocycline so far » SLS, posted by g_g_g_unit on May 23, 2013, at 7:35:46
> > There really isn't enough experience with minocycline for various MI indications to make general statements about its psychotropic behaviors. However, from the few people I know who are taking it, the uncomfortable activation seems to dissipate in a week or less. You might need 100 - 200 mg/day of minocycline to fully benefit from it.
> Thanks for your response. As tempting as it is to continue with minocycline, I'm thinking it might be prudent to discontinue it until I get a better sense of what Parnate's doing. I'm worried I won't be able to tease apart the activating effects of one versus the other.Completely understandable.
Good luck.
- Scott
This is the end of the thread.
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