![[dr. bob]](/dr-bob-sm.gif)
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 11 to 35 of 45. Go back in thread:
Posted by Tomatheus on May 7, 2013, at 11:28:16
In reply to Antipsychotics.. which one??, posted by Lamdage22 on May 7, 2013, at 10:16:51
Lamdage22,
I'm sorry to hear that the akathisia from the Abilify is getting to be really extreme for you.
It might be possible for the tiredness that you experienced on Geodon and Latuda to go away with time. From the anecdotal experiences that I've read regarding antipsychotics, it seems that the fatigue and tiredness that occurs when taking the medications is sometimes reported to go away, but not always. Again, this is just my impression from having read anecdotal reports of how antipsychotics affect people and isn't based on solid scientific evidence by any means.
As far as whether moclobemide could counteract the tiredness from Zyprexa is concerned, I would say it's possible, but I don't know how likely it would be. I know that for me, moclobemide was not helpful against my fatigue and hypersomnia for more than a few days, but there are some who find it to be an effective antidepressant. So, given the fact that moclobemide like any medication can be sort of unpredictable in how it might affect you, it would be, well, hard to predict how well it might counteract the tiredness that you experience from taking Zyprexa.
Well, I'm sorry that my answers to your questions probably didn't turn out to be as concrete as you probably would have liked for them to be, but it can be hard to know in advance how a medication will affect any given person given the individual variations in the ways that people respond to medications. If somebody who's spent a long period of time on Geodon and/or Latuda could chime in and say whether or not they noticed less fatigue and tiredness as they spent more time on the medication, that might help you. Unfortunately, I've never taken Latuda and spent very little time on Geodon because I seemed to become more psychotic on it right away, so I can't speak from experience about the long-term effects of either medication.
T.
Posted by Lamdage22 on May 7, 2013, at 12:29:09
In reply to Re: Antipsychotics.. which one?? » Lamdage22, posted by Tomatheus on May 7, 2013, at 11:28:16
Schizo-Affective disorder sure is a bitch.
I hope ill be alright somehow. Adrenergic substances to counteract the tiredness?
Idk. I hope my doctor will be reasonable and help me out
Posted by Tomatheus on May 7, 2013, at 12:56:58
In reply to Re: Antipsychotics.. which one??, posted by Lamdage22 on May 7, 2013, at 12:29:09
Lamdage22,
See below for my responses to what you've written...
> Schizo-Affective disorder sure is a bitch.
Yeah, isn't that the truth. I just hope you can find a way to manage the disorder to the fullest extent that you can.
> I hope ill be alright somehow. Adrenergic substances to counteract the tiredness?
Using adrenergic substances to counteract the tiredness seems like a possibility. How do you tend to respond to medications that inhibit the reuptake of norepinephrine?
> Idk. I hope my doctor will be reasonable and help me out
I hope so, too. Good luck with everything.
T.
Posted by Lamdage22 on May 8, 2013, at 7:21:21
In reply to Re: Antipsychotics.. which one?? » Lamdage22, posted by Tomatheus on May 7, 2013, at 12:56:58
Schizo-Affective disorder sure is a bitch.
>
> Yeah, isn't that the truth. I just hope you can find a way to manage the disorder to the fullest extent that you can.
>
> > I hope ill be alright somehow. Adrenergic substances to counteract the tiredness?
>
> Using adrenergic substances to counteract the tiredness seems like a possibility. How do you tend to respond to medications that inhibit the reuptake of norepinephrine?A little jittetyand anxious at first. But it increases functioning
>
> > Idk. I hope my doctor will be reasonable and help me out
>
> I hope so, too. Good luck with everything.
>
> T.Thanks!
Posted by Lamdage22 on May 8, 2013, at 7:26:59
In reply to What to do against Abilify akathisia?, posted by Lamdage22 on April 28, 2013, at 6:10:43
Posted by Tomatheus on May 8, 2013, at 11:41:59
In reply to Okay, today no akathisia! Well see (nm), posted by Lamdage22 on May 8, 2013, at 7:26:59
Hi Lamdage22,
It's good to hear that your akathisia seems to have subsided, and I hope that that side effect will continue not to be problematic for you. If you do end up switching to an antipsychotic other than Abilify (although I'm thinking that you'll probably want to keep sticking with the Abilify at least for now, since you're not experiencing the akathisia), then maybe it might make sense to ask your doctor about a medication with NRI properties (such as an SNRI) to combat the tiredness that may come about from taking a different antipsychotic. I just think that that might make sense, given the fact that you've had some success with medications with NRI properties in the past, but I hope that the Abilify will end up working out for you so you won't even need to go that route.
Again, good luck to you!
T.
Posted by Lamdage22 on May 11, 2013, at 4:43:51
In reply to Re: Okay, today no akathisia! Well see » Lamdage22, posted by Tomatheus on May 8, 2013, at 11:41:59
Well.. i will ask my doc to try neurontin with the abilify.
Posted by SLS on May 11, 2013, at 5:27:48
In reply to Damn it, its back., posted by Lamdage22 on May 11, 2013, at 4:43:51
Hi Lamdage22.
> Well.. i will ask my doc to try neurontin with the abilify.
What exactly are you trying to accomplish?
- Scott
Posted by Tomatheus on May 11, 2013, at 11:19:18
In reply to Damn it, its back., posted by Lamdage22 on May 11, 2013, at 4:43:51
Lamdage22,
I'm sorry to hear that the akathisia is back. Are you still taking the Akineton?
T.
Posted by Lamdage22 on May 11, 2013, at 11:23:43
In reply to Re: Damn it, its back. » Lamdage22, posted by SLS on May 11, 2013, at 5:27:48
Hi Scott, mainly i want the Neurontin to counteract the inner restlessness feeling i currently get from Abilify. Possibly it is lightweight akathisia.
Also, i have a bit of social anxiety.
Lastly i have read about glutamate in Schizophrenia. When i took Lamictal without Antipsychotic, i had no psychosis.
Posted by Lamdage22 on May 11, 2013, at 11:25:41
In reply to Re: Damn it, its back. » Lamdage22, posted by Tomatheus on May 11, 2013, at 11:19:18
Thomateus,
yes, today i took 1mg and am fine.
Maybe it weakens. Idk
Posted by Tomatheus on May 11, 2013, at 11:52:14
In reply to Re: Damn it, its back., posted by Lamdage22 on May 11, 2013, at 11:25:41
Hi Lamdage22,
I'm glad that you seemed to notice less as far as restlessness/akathisia is concerned after you took your Akineton today. Have you had a chance to talk to your doctor about the Neurontin yet? Or have you decided to hold off on asking about that for now?
T.
Posted by Lamdage22 on May 11, 2013, at 13:20:36
In reply to Re: Damn it, its back. » Lamdage22, posted by Tomatheus on May 11, 2013, at 11:52:14
Well im in Hospital during the week. Psych Wards are pretty hierarchical here in Germany. The "top doc" said he wants to try approved meds first.
On monday my favorite Dr (who took on my case) is back, so i plan to ask her.
> Hi Lamdage22,
>
> I'm glad that you seemed to notice less as far as restlessness/akathisia is concerned after you took your Akineton today. Have you had a chance to talk to your doctor about the Neurontin yet? Or have you decided to hold off on asking about that for now?
>
> T.
Posted by SLS on May 11, 2013, at 15:28:07
In reply to Re: Damn it, its back., posted by Lamdage22 on May 11, 2013, at 11:23:43
> Hi Scott, mainly i want the Neurontin to counteract the inner restlessness feeling i currently get from Abilify. Possibly it is lightweight akathisia.
>
> Also, i have a bit of social anxiety.
>
> Lastly i have read about glutamate in Schizophrenia. When i took Lamictal without Antipsychotic, i had no psychosis.
>
>
I would think seriously about adding Lamictal and minocycline to your treatment regime.
- Scott
Posted by Lamdage22 on May 11, 2013, at 16:22:00
In reply to Re: Damn it, its back. » Lamdage22, posted by SLS on May 11, 2013, at 15:28:07
> I would think seriously about adding Lamictal and minocycline to your treatment regime.
>
>
> - ScottHi Scott,
yes, but how am i going to convince a "know it all" doctor to do that? I am thinking about lamictal, too. Hes like, yeah thats for bipolar, he says im unipolar. What the hell? Numerous Drs and Psychologists diagnosed me bipolar in the past.
Minocycline.. is that even safe long term?
Im thinking more about lamictal and neurontin.
Posted by Lamdage22 on May 11, 2013, at 16:22:46
In reply to Re: Damn it, its back., posted by Lamdage22 on May 11, 2013, at 16:22:00
I could buy it online without prescription, but doing things without doctor is always a pain in the b*ttocks.
Posted by Lamdage22 on May 12, 2013, at 4:43:31
In reply to Re: Damn it, its back., posted by Lamdage22 on May 11, 2013, at 16:22:46
Hey Scott,
what dosage for the minocycline?
Posted by SLS on May 12, 2013, at 7:08:21
In reply to Scott what dosage?, posted by Lamdage22 on May 12, 2013, at 4:43:31
> Hey Scott,
>
> what dosage for the minocycline?The dosage of minocycline most often studied for depressive and schizoid disorders is 200 mg/day.
Because you responded so well to Lamictal, I think you should think seriously about combining it with minocycline. The combination might work together to produce a greater degree of antiglutamatergic effect.
Minocycline:1. Is neuroprotective.
2. Reduces brain inflammation
3. Reduces the number of glutamate receptors.
4. Demonstrates antidepressant properties in mouse models of depression.
5. Is reported to act synergistically with noradrenergic antidepressants to treat depression - desipramine (but not fluoxetine).
6. Is reported to act synergistically with NMDA antagonists.
7. Reduces glutamate excitotoxicity by reducing the formation of quinolic acid, a NMDA agonist.
8. Reduces mitochondrial release of cytochrome C.
9. Modulates several signaling pathways.
10. Reduces microglial activation.
11. Has been reported anecdotally to successively treat depression.
12. Reduces the expression of lipopolysaccharide-induced pro-inflammation cytokines, an effect that acts as an antidepressant in animal models.
13. Increases neurite growth in response to nerve growth factor (NGF).
14. Inhibits high levels of PKC and GSK-3 alpha;
15. Decreases nitric oxide synthetase, thereby reducing free radicals which damage neurons and glia.
16. Reduces glutamate release.
- Scott
Posted by Lamdage22 on May 14, 2013, at 1:55:32
In reply to What to do against Abilify akathisia?, posted by Lamdage22 on April 28, 2013, at 6:10:43
The Geodon makes me tired, but in a different way than Zyprexa. More like a "normal" tired instead of "zombie tired".
Its day one so i hope it will work out for me.
Posted by SLS on May 14, 2013, at 6:46:17
In reply to They give me Geodon and Abilify now, posted by Lamdage22 on May 14, 2013, at 1:55:32
Hi Lamdage.
> The Geodon makes me tired, but in a different way than Zyprexa. More like a "normal" tired instead of "zombie tired".
>
> Its day one so i hope it will work out for me.I'm glad that your first dose of Geodon didn't produce somnolence or brain-fog. How much did you take?
Good luck!
- Scott
Posted by Tomatheus on May 14, 2013, at 11:38:42
In reply to They give me Geodon and Abilify now, posted by Lamdage22 on May 14, 2013, at 1:55:32
> The Geodon makes me tired, but in a different way than Zyprexa. More like a "normal" tired instead of "zombie tired".
>
> Its day one so i hope it will work out for me.Lamdage22,
I too would like to wish you luck with taking Geodon with Abilify.
T.
Posted by Lamdage22 on May 14, 2013, at 13:02:35
In reply to Re: They give me Geodon and Abilify now, posted by Tomatheus on May 14, 2013, at 11:38:42
I took two times 20mg. Morning and evening.
With currently 15mg Abilify.Akathisia like feeling was kinda strong today :(
Posted by Tomatheus on May 14, 2013, at 19:58:32
In reply to Re: They give me Geodon and Abilify now, posted by Lamdage22 on May 14, 2013, at 13:02:35
Hi Lamdage22,
I'm sorry to hear that the akathisia-like feeling seems worse now that you're taking the Geodon with your Abilify. I would probably try to give the Geodon/Abilify combo some time so you'll get an idea as to how it's going to affect you, unless things get really bad. I hope that somehow the akathisia will eventually subside some.
T.
Posted by Lamdage22 on May 15, 2013, at 1:56:39
In reply to Re: They give me Geodon and Abilify now » Lamdage22, posted by Tomatheus on May 14, 2013, at 19:58:32
I thought about taking the abilify at night perhaps..
That way i may have less of the akathisia. At night i usually feel ok.I know it has a long half life but anyway, isnt it worth a try?
Posted by Tomatheus on May 15, 2013, at 10:56:13
In reply to Re: They give me Geodon and Abilify now, posted by Lamdage22 on May 15, 2013, at 1:56:39
Yeah, taking Abilify at night might be worth trying. As you said, I don't know if it would make a difference given the medication's long half-life, but trying Abilify at night might be worth doing.
T.
Go forward in thread:
Psycho-Babble Medication | Extras | FAQ
Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.org
Script revised: February 4, 2008
URL: http://www.dr-bob.org/cgi-bin/pb/mget.pl
Copyright 2006-17 Robert Hsiung.
Owned and operated by Dr. Bob LLC and not the University of Chicago.