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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 14 of 14. This is the beginning of the thread.
Posted by Tyrannosaur on April 18, 2013, at 22:57:39
What's the different brands of Parnate around the world, and where are they located?
I know there's Jatrosom in Germany, but are there more manufacturers located in Europe?
Posted by Tomatheus on April 18, 2013, at 23:19:48
In reply to Parnate Brands/Manufacturers, posted by Tyrannosaur on April 18, 2013, at 22:57:39
Tyrannosaur,
In the U.S., Parnate is made by Covis Pharma. It was formerly made by GlaxoSmithKline. Par Pharmaceutical also makes a generic version of Parnate for the U.S. market.
I know that a company called Mercury Pharma makes tranylcypromine for the U.K. I'm not sure if a brand-name version of Parnate is available in the U.K.
Those are the only versions of Parnate/tranylcypromine that I know are available. Of course, my knowledge is limited, and I look forward to seeing if anyone else will add to this list that we're putting together.
Tomatheus
Posted by vanvog on April 19, 2013, at 11:48:59
In reply to Re: Parnate Brands/Manufacturers, posted by Tomatheus on April 18, 2013, at 23:19:48
Rising Pharmaceuticals might start marketing "Tranylcypromine sulfate" soon but I guess GSM/Covis is actually the manufacturer behind this product and Rising is just packaging and distributing it but I really don't know anything about this.
http://dailymed.nlm.nih.gov/dailymed/image.cfm?id=79695&type=img&name=8c8dd7fc-7cd1-47ac-a06d-d82604638b08-01.jpg
Jatrosom is as far as know the only Tranylcypromine on the market available in the strength of 20 mg tablets (50 and 100 tablets packs).
In some countries you will STILL find Trifluoperazine + Tranylcypromine as a fixed mixture combo product, like the Parstelin or the old Jatrosom _N_ such products were withdrawn from western markets. "Cuait D" is still available in Argentina for example (0,5 mg Trifluoperazine + 5mg Tranylcypromine) or another such product Parmodalin sold somewhere else.
Posted by Tomatheus on April 19, 2013, at 12:11:17
In reply to Re: Parnate Brands/Manufacturers, posted by Tomatheus on April 18, 2013, at 23:19:48
> In the U.S., Parnate is made by Covis Pharma. It was formerly made by GlaxoSmithKline.
It looks like a correction is in order on my part. It seems that GlaxoSmithKline still manufactures Parnate, but that Covis Pharmaceuticals is the distributor.
See:
http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2e7350bd-ab32-4619-a3f9-12fdf56fc5e2Tomatheus
Posted by Tyrannosaur on April 19, 2013, at 16:17:04
In reply to Re: Parnate Brands/Manufacturers, posted by Tomatheus on April 19, 2013, at 12:11:17
Thanks for the help blabbers.
I'm quite amazed that Mercury Pharma in the UK has the max dose set at 30mg, when so many users on this board claims to use 100mg+ in order to get a good therapeutic effect. To get such a dosage prescribed in the UK must be close to impossible. Also an adequate dose of Parnate is said to be 0.7mg/kg, equivalent of phenelzine 1mg/kg.
Posted by vanvog on April 19, 2013, at 17:43:11
In reply to Re: Parnate Brands/Manufacturers, posted by Tyrannosaur on April 19, 2013, at 16:17:04
Similar to Parnate in the US manufactured by GSK and marketed by Covis, Mercury Pharma is the distributor of Tranylcypromine in the UK, Dales Pharmaceuticals, the UK operation of Dechra Pharmaceuticals is the manufacturer.
>I'm quite amazed that Mercury Pharma in the UK has the max dose set at 30mg, when so many users on this board claims to use 100mg+ in order to get a good therapeutic effect.The max dose of 30 mg is a joke.
Posted by vanvog on April 19, 2013, at 21:46:57
In reply to Re: Parnate Brands/Manufacturers, posted by vanvog on April 19, 2013, at 17:43:11
I found an article on Rising Pharmaceuticals from November 2, 2012:
------------------------------------------
ACETO Subsidiary, Rising Pharmaceuticals, Announces the Signing of Their First Agreement to Market an Authorized Generic Drug (Parnate(R) Product) With Covis Pharma S.a.r.l.PORT WASHINGTON, N.Y., Nov. 2, 2012 (GLOBE NEWSWIRE) -- ACETO Corporation (ACET), a global leader in the marketing, sale and distribution of products for Human Health, Pharmaceutical Intermediates and Performance Chemicals, today announced that Rising Pharmaceuticals Inc., its finished dosage form generics subsidiary, has signed a definitive agreement to market an authorized generic of the 10mg strength of Tranylcypromine Sulfate Tablets, an FDA approved authorized generic version of Covis Pharma's Parnate® product. According to IMS Health data, U.S. market sales for Tranylcypromine Sulfate Tablets, which is used for the treatment of depression, were approximately $8 million for the twelve months ended June 2012.
------------------------------------------The last sentence contains a very interesting piece of information because a) $8 million is like "nothing" in the world of (big) pharma and b) the number can give you a good estimation of current Parnate users in the US. Something like 3000 to 5000 CONTINUOUS Parnate patients? That seems a surprisingly low number but that might be just for the generic Tranylcypromine Sulfate, brand name Parnate sales are probably much higher, unfortunately I couldn't find any mention of Parnate in GSK's old Annual Reports or any data on the Parnate (brand-name) market. I found some reliable info from 2004 saying that in Germany (population 82 million) there were ~6800 Parnate patients that year. I remember reading something about 30000 Parnate users in the world but I really don't know where this number came from or how accurate it is.
Another thought, I think there were many more manufacturers of Tranylcypromine some years ago but in a series of acquisitions the market for Parnate consolidated leaving GSK and just one generic manufacturer (in the US), also in many countries no generic Parnate is available, probably the market there is relatively small as it is leaving no place for profitable generic niche. In some developed countries like Japan and some European countries there is apparently NO Parnate brand-name or generic available at all, go figure.
Posted by Tyrannosaur on April 20, 2013, at 0:04:02
In reply to Re: Parnate Brands/Manufacturers, posted by vanvog on April 19, 2013, at 21:46:57
I read recently that there were just a few thousand continuous prescriptions written for Nardil in the U.S, so Parnate seems to be by far more popular. In Europe i believe most MAOIs were used in a lot of countries until around late 80's ~ early 90's when they were removed from most markets due to the increased use of SSRI and overblown tyramine risk.
At least that's the case in the country i reside in, but it's still possible to import these meds if you're lucky and find an open minded pdoc.
Posted by vanvog on April 20, 2013, at 2:06:04
In reply to Re: Parnate Brands/Manufacturers, posted by Tyrannosaur on April 20, 2013, at 0:04:02
AJN, American Journal of Nursing:
January 2000 - Volume 100 - Issue 1, PART 1 OF 2 - p 71
Drug Watch----------------------------
MAOI PRESCRIPTIONS: Way down, but still not out
Only 2% of psychiatrists recently surveyed reported prescribing monoamine oxidase inhibitors (MAOIs) frequently. This is down from 25% 10 years ago, before the widespread use of selective serotonin reuptake inhibitors (SSRIs).
The most common explanation for never or rarely prescribing MAOIs was potential interactions. Other reasons were side effects, a preference for other drugs, potential legal complications, the dietary restrictions required for patients receiving MAOIs, lack of training regarding their use, and lack of belief in their efficacy.
Meanwhile, the majority of respondents, 92%, acknowledged the usefulness of MAOIs for treating atypical depression, and a substantial percentage found them useful for major depression (melancholic type), panic disorder, social phobia, and other disorders. They are particularly useful for patients who don't respond to SSRIs and can't tolerate the side effects associated with tricyclic antidepressants.
MAOIs are prescribed infrequently, but it's important to be aware of their potential side effects (such as postural hypotension, insomnia, and headache) and the risk of hypertensive crisis with concomitant sympathomimetics, levodopa, and high-tyramine foods such as cheese, chocolate, wine, beer, and coffee.
Source: Balon R, et al. A survey of prescribing practices for monoamine oxidase inhibitors. Psychiatr Serv 1999;50(7):945-47. Full text: http://psychiatryonline.org/data/Journals/PSS/3519/945.pdf
----------------------------
Posted by Tyrannosaur on April 20, 2013, at 7:17:19
In reply to Re: Parnate Brands/Manufacturers, posted by vanvog on April 20, 2013, at 2:06:04
The future does indeed seem dark for MAOIs, medical students barely learn anything at all about MAOIs in school, thus they'll barely have any knowledge about them if they choose to become pdocs. MAOIs get prescribed less and less over the years because of this. And most old pdocs which still have a great deal of experience with them are slowly retiring.
I wonder if Tranylcypromine and Phenelzine will go off the market for good at some point. Phenelzine will definitely be the first one to go since it's the least used of the two. They're among the most efficient antidepressants available, their situation is just ludicrous.
Posted by vanvog on April 20, 2013, at 23:14:35
In reply to Re: Parnate Brands/Manufacturers, posted by Tyrannosaur on April 20, 2013, at 7:17:19
I remember Chairman_MAO has written about how he was buying Tranylcypromine powder either as sulfate or hydrochloride, making his own Parnate capsules but if I remember correctly he had to cut his dose later on because after a price increase the stuff became too expensive.
I checked some API and chemical suppliers on the internet and most no longer offer Tranylcypromine while those who still do sell only very small amounts for ridiculous prices, I have actually seen 500mg for $60.
Is anyone still buying or plans to buy Tranylcypromine powder in bulk, have you heard anything about it recently?
Posted by jono_in_adelaide on April 22, 2013, at 0:15:03
In reply to Re: Parnate Brands/Manufacturers, posted by Tomatheus on April 18, 2013, at 23:19:48
There is also an Australian Parnate, but i suspect that due to the small demand in Australia, it is American or British Parnate just packed up for the Australian market
Posted by Tyrannosaur on April 22, 2013, at 1:08:09
In reply to Re: Parnate Brands/Manufacturers, posted by jono_in_adelaide on April 22, 2013, at 0:15:03
> There is also an Australian Parnate, but i suspect that due to the small demand in Australia, it is American or British Parnate just packed up for the Australian market
Yes, the Australian version of Parnate is produced by the UK company Mercury Pharma.
Posted by vanvog on April 22, 2013, at 19:17:03
In reply to Re: Parnate Brands/Manufacturers, posted by Tyrannosaur on April 22, 2013, at 1:08:09
Not that it is really of interest, for the sake of completeness though, JATROSOM is manufactured by Aristo Pharma and co-marketed by esparma, both companies are located in Germany.
This is the end of the thread.
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