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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 9 of 9. This is the beginning of the thread.
Posted by FrequentFryer on March 30, 2013, at 21:35:17
Hi All
My psych put me on Baclofen for Anxiety which is a GABA B agonist (and I think has a positive influence on Dopamine). Well I dunno really the mechanism of action is unknown. It's almost identical to Gabapentin and Pregabalin. Anyways it makes me interested in stuff for the first time in years and has a very strong pro social and anxiolic effect (Heaps better the Clonazapam in my opinion). The only problem is you get a strong tolerance to it (like everything) very quickly.I would defiantly recommend giving it a try at 50 to 75mg's. It's not controlled and is cheap (in Australia).
I was wondering if anyone else has had any luck with other GABA drugs for Anxiety Depression?
Regards.
FF.
Posted by Hugh on March 30, 2013, at 21:52:17
In reply to I think Gaba B might be key for TRD and Dysthymia, posted by FrequentFryer on March 30, 2013, at 21:35:17
I was taking baclofen for muscle spasms in my lower back, and was shocked when it wiped out my depression and anxiety. Unfortunately, I had to stop taking it after a week because it caused such bad insomnia. As far as I know, the only other GABA-B agonist is GHB. The End of My Addiction by Olivier Ameisen contains a lot of information about baclofen.
Posted by Phillipa on March 31, 2013, at 9:53:29
In reply to Re: I think Gaba B might be key for TRD and Dysthymia, posted by Hugh on March 30, 2013, at 21:52:17
Baclofen have another name? Phillipa
Posted by cassandracomplex on March 31, 2013, at 13:45:53
In reply to I think Gaba B might be key for TRD and Dysthymia, posted by FrequentFryer on March 30, 2013, at 21:35:17
I don't think it's that simple. I don't think that TRD is a "one-size-fits-all" diagnosis from a neurochemical perspective. Why do amphetamines - which release DA and NE - relieve depression in many (in fact, were some of the first medications on label here in the US to treat depression) and yet lead to depression in others? The same goes for adjunctive antipsychotic medication, which inhibits DA. Why does MDMA have a short-lived response rate in nearly everyone who takes it, even those with major depression, and yet causes a profound "crash" in some afterward - certainly in most who use it on a prolonged basis, and yet its effects are entirely blocked by SSRIs/SNRIs. Why do benzodiazepines worsen depression in some but not all? Why doesn't Ketamine have a 100% response rate? Why doesn't Xyrem/GHB? This is why, I think, so-called "dirty drugs" have proven superior in treating TRD (and there are still those who fail to respond to those/require augmentation): because we're talking about more than one neurobiological process here. There is no one key that opens dozens of different locks. JMHO.
Posted by Hugh on March 31, 2013, at 17:22:45
In reply to Re: I think Gaba B might be key for TRD and Dysthymia, posted by cassandracomplex on March 31, 2013, at 13:45:53
> There is no one key that opens dozens of different locks. JMHO.
Mark George, one of the first to use TMS to treat depression, thinks it would make more sense to call depression "the depressions" since there are so many different kinds of it.
Posted by FrequentFryer on March 31, 2013, at 17:39:37
In reply to Re: I think Gaba B might be key for TRD and Dysthymia » Hugh, posted by Phillipa on March 31, 2013, at 9:53:29
> Baclofen have another name? Phillipa
Baclofen is the chemical name
Posted by FrequentFryer on March 31, 2013, at 17:49:39
In reply to Re: I think Gaba B might be key for TRD and Dysthymia, posted by cassandracomplex on March 31, 2013, at 13:45:53
> I don't think it's that simple. I don't think that TRD is a "one-size-fits-all" diagnosis from a neurochemical perspective. Why do amphetamines - which release DA and NE - relieve depression in many (in fact, were some of the first medications on label here in the US to treat depression) and yet lead to depression in others? The same goes for adjunctive antipsychotic medication, which inhibits DA. Why does MDMA have a short-lived response rate in nearly everyone who takes it, even those with major depression, and yet causes a profound "crash" in some afterward - certainly in most who use it on a prolonged basis, and yet its effects are entirely blocked by SSRIs/SNRIs. Why do benzodiazepines worsen depression in some but not all? Why doesn't Ketamine have a 100% response rate? Why doesn't Xyrem/GHB? This is why, I think, so-called "dirty drugs" have proven superior in treating TRD (and there are still those who fail to respond to those/require augmentation): because we're talking about more than one neurobiological process here. There is no one key that opens dozens of different locks. JMHO.
I know I made the heading like that in hopes lots of people would have a read,It's just I have hammered all my other transmitters so much gaba is the only one left with some sensitivity I think. just wanted to know if anyone else out there had had any luck with similar GABA agents in monotherapy or augmentation like Gabatril, Phenibut, Pregabalin, Gabapentin and any ways I could reduce my tollerance to the Baclofen like I dunno would GABA suppliments help?
Posted by Hugh on April 1, 2013, at 11:50:34
In reply to Re: I think Gaba B might be key for TRD and Dysthymia » Hugh, posted by Phillipa on March 31, 2013, at 9:53:29
> Baclofen have another name? Phillipa
Lioresal and Kemstro are probably the most common brand names.
Posted by Phillipa on April 1, 2013, at 19:18:06
In reply to Re: I think Gaba B might be key for TRD and Dysthymia » Phillipa, posted by Hugh on April 1, 2013, at 11:50:34
Hugh thanks I've heard of lioresal. Now google. Phillipa
This is the end of the thread.
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