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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by poser938 on March 26, 2013, at 17:10:32
When a medication has "negligable affinity for a receptor", would taking much higher doses thasn is usually prescribed cause this medicine to have a prominent effect at that receptor?
I'm referring tyo cyproheptadine and the a1 and a2 receptors.
Posted by jono_in_adelaide on March 26, 2013, at 17:45:17
In reply to negligable affinity for a receptor, posted by poser938 on March 26, 2013, at 17:10:32
It might, but given that you'd have to take it in extreme doseages, its likely that you'd start to get toxic effects before you got the effect that you were looking for.
Posted by poser938 on March 26, 2013, at 17:52:56
In reply to Re: negligable affinity for a receptor, posted by jono_in_adelaide on March 26, 2013, at 17:45:17
> It might, but given that you'd have to take it in extreme doseages, its likely that you'd start to get toxic effects before you got the effect that you were looking for.
I took extremely hig doses of cyproheptadine. Probably enough to kill a moose if he wasn't tolerant to it. I got myself tolerant to it. But I'm just still thinking about the a2 antagonism from mirtazapin you mentioned, and I'm not sure if id be tolerant to that effect as well from past cyproheptadine.
Posted by linkadge on March 26, 2013, at 20:16:56
In reply to Re: negligable affinity for a receptor, posted by poser938 on March 26, 2013, at 17:52:56
I suppose it depends on how high the dose, and how negligible the affinity.
Posted by jono_in_adelaide on March 26, 2013, at 23:32:04
In reply to Re: negligable affinity for a receptor, posted by poser938 on March 26, 2013, at 17:52:56
I doubt you'd be tolorant given how potent mirtazapine is in relation to cyproheptadine
I'd try mirtazapine and see how it works for you
Posted by poser938 on March 27, 2013, at 16:40:32
In reply to Re: negligable affinity for a receptor, posted by jono_in_adelaide on March 26, 2013, at 23:32:04
Yeah I'll try it
Posted by jono_in_adelaide on March 27, 2013, at 19:00:22
In reply to Re: negligable affinity for a receptor, posted by poser938 on March 27, 2013, at 16:40:32
Good work Poser - you have nothing to lose and everything to gain.
Start off at 15mg, and work up to 30mg, then, if needed, to 45mg
Note that the side effects tend to be worse at lower doseages (drowsiness in particular0 so dont ditch it until you have reached 45mg and stayed there for a good few weeks.
Best of luck!
This is the end of the thread.
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