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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 7 of 7. This is the beginning of the thread.
Posted by baseball55 on February 1, 2013, at 18:49:20
Just curious about this, since I just read Awakenings. Parkinson's seems to be caused by a lack of dopamine and managed with dopamine-enhancing drugs. Yet AP's increase dopamine and the most dangerous side-effects are parkinsonian symptoms (tremors, tics, myclonic jerks, etc). Just wondering if anyone here understands this.
Posted by Phillipa on February 1, 2013, at 23:00:26
In reply to curious about dopamine, posted by baseball55 on February 1, 2013, at 18:49:20
No I don't it's confusing? I haven't read it good book? Phillipa
Posted by Phillipa on February 1, 2013, at 23:07:49
In reply to curious about dopamine, posted by baseball55 on February 1, 2013, at 18:49:20
Have you read his other books they do sound good. Here's a website to his book on Amazon. Phillipa
Posted by linkadge on February 2, 2013, at 17:52:08
In reply to Re: curious about dopamine, posted by Phillipa on February 1, 2013, at 23:07:49
APs don't increase dopamine. They block dopamine receptors (i.e. *lowering* dopaminergic neurotransmission). The exception is the prefrontal cortex, where the atypicals may increase dopamine release. The movement related side effects are due to the fact that APs lower dopamine signalling in motor control regions of the brain.
Linkadge
Posted by SLS on February 2, 2013, at 18:12:56
In reply to Re: curious about dopamine, posted by linkadge on February 2, 2013, at 17:52:08
Hi Linkadge.
I hope all is well with you. That we don't see you here very often must be a good sign.
Are you still taking amitriptyline and mirtazapine?
- Scott
Posted by SLS on February 2, 2013, at 18:15:57
In reply to Re: curious about dopamine, posted by linkadge on February 2, 2013, at 17:52:08
Oh. I forgot to ask. Do you recall where you found the information regarding hyperactivity in the nucleus accumbens contributing to the development of depression?
Thanks.
- Scott
Posted by linkadge on February 6, 2013, at 18:08:25
In reply to Re: curious about dopamine » linkadge, posted by SLS on February 2, 2013, at 18:12:56
I am doing alright. I am actually taking california rocket fuel ++
The ++ stands for + ritalin. So mirtazapine, effexor and ritalin. The doses of each are very low. 7.5mg 37.5mg and 5mg respectively. Actually the doses tend to be less than this as I don't take everything every day.
In rats, prolonged exposure to pleasurable stimuli, i.e. stimulants, opioids, highly palatable food increases depresive symptoms.
http://www.webmd.com/depression/news/20050728/dopamine-may-play-new-role-in-depression
SSRIs may in fact be working by supressing dopamine function - or, at least counterballancing dopamine with serotonin in many individuals. There is a strong link between addictive personalities, OCD and depression. This might be associated with high dopamine and low serotonin / gaba.
This is the end of the thread.
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