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Dr. Bob is Robert Hsiung, MD,
bob@dr-bob.orgShown: posts 1 to 2 of 2. This is the beginning of the thread.
Posted by SLS on December 3, 2012, at 18:27:45
Hi Ed.
How have you been? Are you in a good place?
- Scott
Posted by ed_uk2010 on December 4, 2012, at 9:01:15
In reply to How are you? » ed_uk2010, posted by SLS on December 3, 2012, at 18:27:45
Hi Scott,
I'm not at all bad thanks. Mostly well :) I see quite a few familiar names are still here. Not seen any posts by Linkadge though.
I wondered whether you would be interested in my post to RJLockhardt further up the page. He was asking about drugs penetrating the blood brain barrier. I'll post it again here...
Some drugs which do cross the blood brain barrier are pumped back out of the brain by a molecule called p-glycoprotein (also called multi-drug resistance protein or ABCB1). P-gp activity is controlled by genetics and can be inhibited by various drugs. Some psychiatric drugs are pumped back out of the brain by P-gp, and genetic differences in P-gp activity may partly account for why some people require higher doses of antidepressants than others. Drugs which inhibit P-gp may increase the effects of other drugs which would otherwise be pumped back out of the brain by P-gp. Certain SSRIs are believed to be P-gp inhibitors.
Many psych drugs are substrates of P-glycoprotein....
[Pharmacokinetic mechanisms underlying resistance in psychopharmacological treatment. The role of P-glycoprotein].
http://www.ncbi.nlm.nih.gov/pubmed/16314897
Some psych drugs inhibit P-glycoprotein....
http://www.ncbi.nlm.nih.gov/pubmed/12649369
And genetic differences in P-glycoprotein activity may affect response to psych medication...
http://www.ncbi.nlm.nih.gov/pubmed/23188198
......This equates to a 2.0 fold greater escitalopram dose needed to remit for C carriers compared with TT carriers.....and for venlafaxine-treated subjects carrying TT genotype, 73.3% remitted compared with 12.5% for CC genotype.
This is the end of the thread.
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